Decoding the human brain is perhaps the most fascinating scientific challenge in the 21st century. The Human Brain Project (HBP), a 10-year European Flagship, targets the reconstruction of the brain's multi-scale organization. It uses productive loops of experiments, medical, data, data analytics, and simulation on all levels that will eventually bridge the scales. The HBP IT architecture is un...

The inhibitor), effect of hop bract polyphenols (HBP) on cariogenic streptococci was investigated. It wu'as fbund that the high molecular weight polyphenol (estimated about 36,OeO-40,OOO) inhibited the cellular adherence of Streptoeoccus mutans MT8148 (serotype C) and Streptoeoeeus sobrinus ATCC 33478 (serotype g) at msuch smaller concentrations than the polyphenols extracted from oe)ong tea or...

BACKGROUND Magnesium is known to lower the risk of cardiovascular disease. However, studies on its relationship with hypertension, a single and common cause of various chronic diseases, are limited and their findings are not consistent. The purpose of the present study is to identify the relationship between magnesium intake and high blood pressure (HBP) risk in Koreans. METHODS This research...

Most oil and gas leases allow the operator to extend possession for an indefinite period by establishing production in paying quantities. We show how this option to “hold by production” (HBP) stimulates the drilling of many wells that would otherwise be uneconomic. Although such wells may superficially appear to be poor investments, in fact they contribute to shareholder value. We also show, ho...

BACKGROUND Sepsis-related acute kidney injury (AKI) accounts for major morbidity and mortality among the critically ill. Heparin-binding protein (HBP) is a promising biomarker in predicting development and prognosis of severe sepsis and septic shock that has recently been proposed to be involved in the pathophysiology of AKI. The objective of this study was to investigate the added predictive v...

The hexosamine biosynthesis pathway (HBP) serves as a nutrient sensor and has been implicated in the development of type 2 diabetes. We previously demonstrated that fatty acid oxidation was enhanced in transgenic mouse adipocytes, wherein the rate-limiting enzyme of the HBP, glutamine:fructose-6-phosphate amidotransferase (GFA), was overexpressed. To explore the molecular mechanism of the HBP-i...

Infectious diseases remain a major health problem, where sepsis and other severe infectious diseases are common causes of morbidity and mortality. The importance of early and appropriate treatment of sepsis and severe bacterial infections has been underlined by the successes of measures like the Surviving Sepsis Campaign, among others. Thus, there is a need for clinical and laboratory tools to ...

BACKGROUND Angiotensin II receptor blocker (ARB) as a first-line drug for hypertension in diabetes often fails to control blood pressure adequately. The objective of the study was to evaluate the effect of amlodipine combined therapy on home blood pressure (HBP) useful for management of hypertension. METHODS AND RESULTS A total of 263 type 2 diabetes with hypertension refractory to standard d...