بررسی اثر غلظت‌های مختلف پودر میوه هندوانه ابوجهل (حنظل) بر برخی فاکتورهای بیوشیمیایی خون در موش‌های صحرایی نر دیابتی شده

  Background and Objectives : Diabetes is one of the most common endocrine diseases. The aim of the present study was to examine the effect of the different concentrations of Citrullus colocynthis fruit powder that its anti-diabetics effects had been reported, on some of blood glucose, cholesterol and TG in diabetic male rats.   Materials and Methods: In this experimental study, 40 rats divided in 4 groups with 10 members. Three groups received the amounts of 1%, 2% and 5% concentrations of the Citrullus colocynthis fruit powder at the basal diet daily for 28 days and diabetic control group had basic diet without any Citrullus colocynthis. Blood sample were collected from eyes at the beginning and the end of the experiment then some biochemical factors were measured. Data analysis was performed using Paired t-test, and one-way ANOVA followed by multiple comparisons of Tukey test.   Results : Consumption of different concentration of Citrullus colocynthis fruit powder reduced significantly the plasma level of blood glucose, cholesterol and TG (p<0.05 ).   Conclusion : Citrullus colocynthis with concentrations used in this study suggested positive effect on the reduction of sugar and some lipids in diabetes disease. Compared with different concentrations, 5%, 1% and 2% concentrations of Citrullus colocynthis showed the most reduction in blood glucosd, cholesterol, and TG, respectively.   Key word : Diabetes mellitus, Citrullus Colocynthis, Rat     Funding : This study was funded by Rafsanjan University of Medical Sciences .   Conflict of interest : None declared.   Ethical approval: The Ethics Committee of Rafsanjan University of Medical Sciences approved the study .     How to cite this article : Mahmoodi M, Sayyadi AR, HosseiniZijoud SM , Hajizadeh M.R, Kazemi Arababadi M, Asadikaram G.R , Mirzai MR, Poladvand V, Sadeghi A, Shamsi zadeh A, Hassanshahi G.H. Survey on the Effects of Different Concentrations of Citrullus Colocynthis Fruit Powder on Some of the Blood Biochemical Factors in Normal and Diabetic Male Rats . J Rafsanjan Univ Med scie 2012 11(1): 11-20. [Farsi]