بررسی فراوانی وجود آنزیم لاکتاماز در باکتری های جدا شده از -βعفونت های پوستی و زخم های عفونی بیمارستانی در بیمارستان فوق تخصصی امام خمینی شهرستان ساری در سال 13

Background and purpose: Hospital infections are common throughout the world. Antibiotic resistance is caused after infectious diseases and hospital infections. Considering the importance of hospital infection and bacteria resistant to antibiotics, this study aimed at investigating the prevalence of β-lactamase enzymes in bacteria isolated from nosocomial infections. Material and Methods: Fifty samples of skin infections and 50 samples from wounds were collected from Imam Khomeini Hospital in Sari and were studied using biochemical tests and identification of beta-lactamase. Results: In this study, 180 organisms were isolated from 100 samples of skin infections and wound. The production of β-lactamase enzymes by acidimetric method in these samples showed that 26 samples (14.4%) were β-lactamase positive and 154 samples (85.6%) were β-lactamase negative and gram positive cocci and bacilli. Conclusion: β-lactamase positive bacteria not only increase the risk of nosocomial infections, especially skin infections in people with weakened immune systems but also make them resistant to β- lactam group of antibiotics.