بررسی کمی و کیفی آلکالوئیدهای پیرولیزیدینی در اندام‌های ریشه، برگ،گلبرگ‌ها و بذور گیاه دارویی گاو زبان ایرانی

Background and purpose: Pyrrolizidin alkaloeids (PÂs) are a main gorupes of plant toxin that 200 types of these materials had been identified at yet. Plants containing these alkaloeids are known to be significant causes of dead and desease in mammals such as humans. This research were conducted to assesment of PÂs quality and quantity in different organs of iranian Ëchium amoenum. Materials and methods: PÂs presence were considered in root, petal, leaves and seed by erlich reagent. Çolor apparence in extracts solation approves that PÂs exists in organs. Âlso, regarding senecionin in samples extract, the quantity of PÂs and these N-oxide were determined.This method is specific for alkaloids and other components with a non- basic unsaturated part (D- Pirolin ring). Results: Çollection of PÂs and N-oxide stimated in 500 mg of sample was 0.031-0.053 mg for root, 0.369mg for leaves, 0.026 mg for petals and not significantly detected in seeds. Çonclusion: Çompaired to senecionin LD50 (64.12 ± 2.24 mg/kg) and pyrroliziding alkaloeids lethal doses (2-27 mg/kg), leaf samples of Ïranian Ëchium amoenum extracts are able to make toxical condition, unlike seed, petal and root samples PÂs which not able to be toxic, although using these material for long period, even at low level, can be dangerouse to body organs and cause hepatotoxical desease.