تأثیر مکمل دو هفته‌ای 2-امینواتان سولفونیک اسید بر سطح سرمی شاخص‌های لیپیدی و التهابی بیماران با نارسایی قلبی مراجعه‌کننده به مرکز لقمان حکیم متعاقب اجرای برنامه بروس

  Background and Objectives : Recent studies the reverse relation between 2-aminoethanesulfonic acid concentrations and cardiovascular risk factor was investigated in animal models, the effect of 2-aminoethanesulfonic acid (2-AESA) supplementation on lipid and inflammatory profile in humans, particularly have been poorly investigated in patients with Cardiac heart failure (CHF) following Bruce protocol. The aim of this study was to assess the effect of the 2-AESA supplementation on the lipid and inflammatory profile in patients with CHF after Bruce protocol.   Materials and Methods : In this clinical trial study sixteen male patients between 50 to 65 years, were randomly divided into the 2-AESA and placebo groups. The 2-AESA group received 1.5 gr., 3 times a day in 500 milligram capsules and at the same time, the placebo group useed the starch capsules for two weeks. The plasma 2-AESA, lipid profile (TC, TG, LDL-C and HDL-C), C-reactive protein (CRP) concentrations and systolic and diastolic blood pressures, and heart rate were measured before and after the 2-AESA supplementation and Bruce protocol by using standard methods. Data was analyzed by using dependent and independent t-student tests.   Results : The 2-AESA supplementation for 2 weeks increased the plasma 2-AESA concentration(p< 0.001), and therefore decreased CRP (p=0.031), TC (p=0.024), LDL-C (p=0.042) and increased HDL-C (p=0.046) concentrations in comparison with placebo group. In addition, performing Bruce protocol following the 2-AESA supplementation showed a decrease in systolic and diastolic blood pressures, and heart rate levels in comparasion with placebo group (p=0.029, 0.020 and 0.048, respectively).   Conclusion : These data indicate the hypolipidemia and anti-inflammatory roles of the 2-AESA supplementation in patients with CHF after a standard activity. Therefore, the consumption of 2-AESA can be recommended to people with CHF as a preventive nutrition strategy.   Key words: 2-Aminoethanesulfonic Acid, Lipid Profile, Antioxidants, Cardiovascular risk factors, Bruce Protocol.   Funds: The required fund was allocated by personal contribution.   Conflict of interest: None declared.   Etical approval: The Ethics Committee of Shahid Beheshti University of Medical Sciences, approved the study .   How to cite this article : Kadkhodaei khalafi M, Dabidi Roshan V. Effect of 2-Aminoethanesulfonic Acid on Serum Level of the Lipid and inflammatory Indexs in Cardiac Patients Reffering to Loghman Hakim Center after Bruce Protocol . J Rafsanjan Univ Med Scie 2012 11(4): 323-336. [Farsi]