Diagnostic reliability check of red cell indices in differentiating Iron Deficiency Anemia (IDA) from Beta Thalassemia Minor (BTT)
نویسندگان
چکیده مقاله:
Introduction: Iron deficiency anemia and beta-thalassemia trait are the two most common causes of hypochromic microcytic anemia. There are some discriminating functions (DFs) formula to differentiate these two conditions based on RBC's indices which would be compared the validity of the 14 various indices in this study. Correspondence: Mostafa Ravanbakhsh, MD. Department of Pathology, Hazrat-E- Abolfazl Hospital, Hormozgan University of Medical Sciences. Minab, Iran Tel:+98 9177675403 Email: [email protected] Methods: A total of 227 patients from 21st March to 21st June 2014 were studied by calculating 14 DFs i.e. Keikhaei (KI), RDWI, Green & King (G & KI), England & Fraser (E & FI), Mentzer (MI), Shine & Lal (S & LI), Telmissani (TI), Ricerca (RI), Ehsani (EI), Keli (RBC) and 4 new indices (F1, F2, F3 & F4). The study included 105 iron deficient patient and 122 beta-thalassemia trait cases (HbA2>3.5 & HbA2<8%). The number of correctly diagnosed cases were determined and sensitivity, specificity, positive and negative predictive value and Youden index of each discrimination index were calculated. Results: None of the indices showed 100% sensitivity and specificity. G & KI, KI, RDWI, E & FI, F3, EI and MI showed the highest value in differentiating IDA from BTT. The lowest value was belong to S & LI, F4 and F2 indices. Conclusion: Based on Youden index (YI), the value of discrimination function indices from highest to lowest was as follow: G & KI> KI> RDWI> E & FI> F3> EI> MI> RBC> F1> RI> F2> F4> S & LI.
منابع مشابه
Evaluation of the Formulae Based on Red Blood Cell Indices in Differentiating Between Iron Deficiency Anemia and Beta Thalasemia Minor
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عنوان ژورنال
دوره 20 شماره None
صفحات 151- 157
تاریخ انتشار 2016-08
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