Prevalence of HBe Ag and LFT Survey in HBsAg Positive Blood Donors in Kerman

نویسندگان

  • H Ferdowsi Intern, School of Medicine, Kerman University of Medical Sciences and Health Services, Kerman, Iran
  • L Mozafarian Intern, School of Medicine, Kerman University of Medical Sciences and Health Services, Kerman, Iran
  • M Haiatbakhsh Assistant Professor of Internal Medicine,
  • M.J Zahedi Assistant Professor of Internal Medicine
  • S Darvish-Moghaddam Assistant Professor of Internal Medicine,
چکیده مقاله:

The hepatitis-B virus (HBV) is one of the most common chronic pathogens in the world. More than 2 billions of world population have been exposed to this virus and 350 millions of them (5% of world population) are chronic carriers of HBV. One of the most common routes of transmission of this virus is blood products and transfusion . For this reason blood transfusion organization controls all of the blood products for HBsAg . In HBV chronic carriers the state of viral replication should be determined by suitable antigenic markers such as HBeAg. So people who are HBeAg positive and have elevated liver functien test (LFT) be recognized and treated as chronic hepatitis. The aim of this study was to determine people who are HBeAg positive, elevated LFT in HBsAg individuals, and recognition of chronic hepatitis patients in Kerman during the year of 1378. This study was conducted on 300 HBsAg people who were between 17-65 years of age. According to the results 29 persons (9.6%) were HBeAg positive with no significant correlation between the two Measurement of LFT at the same time showed that 12 HBeAg positive persons( 14.4%) had higher serum AST levels (≥47 IU/L) and 13 of them (44.8%) had higher serum ALT levels (>47IU/L) .Overall in 10 HBeAg positive persons both AST and ALT were elevated but only in 19 HBeAg negative persons (7.1%) both ALT and ALT showed elevation. Generally HBeAg positivity is considered a risk factor for elevated aminotransferase levels (P<0.00001). The liver synhetic function tests including PT, serum albumin , total protein and bilirubin did not have any statistically difference in HBeAg positive and negetive patients (P>0.05).The results indicated that in HBsAg blood donors chronic hepatitis is prevalent in a significant number but severe liver disease is absent .

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The prevalence and probable risk factors of HbsAg positive blood donors in Mazandaran province in 2013

Abstract Background and Objectives HBV, a classic viral Transfusion Transmitted Infection(TTI), is considered an important health and blood safety issue in every society. Prevalence of HBsAg positivity is variable among Iranian blood donors nationwide. This study was performed to determine the frequency of HBsAg positive blood donors and the probable associated risk factors in Mazandaran provi...

متن کامل

Significance of tests for HBeAg and anti-HBe in HBsAg positive blood donors.

A sensitive radioimmunoassay method for HBeAg and anti-HBe allowed 98.4% of HBsAg positive blood donors to be classified. HBeAg was more prevalent in blood donors under 30 years of age and anti-HBe was more prevalent in those over 30 years. The mean HBsAg concentration was four times greater in donors with HBeAg than in those with anti-HBe. No significant associations were found with sex, blood...

متن کامل

Association between HBe-Ag and HBV-DNA level in HBsAg positive chronic carriers

Background: Viral hepatitis is one of common infectious diseases and known as health problem around the world. Present cross-sectional study was performed to determine the association between HBeAg and HBV-DNA in patients who referred to Royan Institute for Reproductive Biomedicine and Amiralmomenin Hospital (Islamic Azad University) between 2012 and 2015. Materials and methods: In this cross-s...

متن کامل

Serosurveillance of HBsAG Positive Patients in Voluntary Blood Donors

Blood transfusion is the process of transferring blood or blood products from one person to another. Blood transfusion can lead to the transfer of many infectious agents which can lead to Transfusion Transmitted Diseases. HBsAg is one of such infectious diseases, which leads to Hepatitis B Infection. The hepatitis B virus (HBV) is a DNA virus and a member of the hepadna family of viruses, and i...

متن کامل

Prevalence of Occult Hepatitis B Infection among HBsAg Negative Blood Donors in Golestan Province

Background and Aims: Occult hepatitis B virus infection (OBI) is known as an important source of hepatitis B virus (HBV) infection. It is categorized as Hepatitis B surface antigen (HBsAg) not being present and low DNA viral load in serum. In this study, an attempt was made to investigate the outbreak of anti-HBc and OBI among the HBsAg-negative donors in Golestan province. Materials and Metho...

متن کامل

Prevalence of anti-HBc in HBsAg negative blood donors using two enzyme immunoassays kits

Abstract Background and Objectives Use of kits with high sensitivity and specificity to determine the prevalence of antibodies against hepatitis B virus (anti-HBc) core antigen is important. The aim of this study was to determine the prevalence of hepatitis B virus antibody in HBsAg negative blood donors using two anti-HBc enzyme immunoassay kits (DIA.PRO and SIEMENS).   Materials and Methods...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره 10  شماره 3

صفحات  123- 130

تاریخ انتشار 2003-07-01

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023