Review Paper: Embryonic Stem Cell and Osteogenic Differentiation

نویسندگان

  • Hossein Salehi Rozveh Department of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Reza Samanipour Department of Nuclear Engineering, Faculty of Basic Science and Nuclear Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Iran.
چکیده مقاله:

Bone tissue engineering has been one of the most promising areas of research, providing a potential clinical application to cure bone defects. Recently, various stem cells, including embryonic stem cells (ESCs), bone marrow-derived mesenchymal stem cells (BM-MSCs), umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs), adipose tissue-derived stem cells (ADSCs), muscle-derived stem cells (MDSCs), and dental pulp stem cells (DPSCs) have received extensive attention in the field of bone tissue engineering due to their distinct biological capability to differentiate into osteogenic lineages. Application of these stem cells to bone tissue engineering requires their in vitro differentiation into bone forming cells, osteoblasts. For this purpose, efficient in vitro differentiation towards osteogenic lineage requires the development of well-defined and proficient protocols. This protocol would reduce the likelihood of spontaneous differentiation into divergent lineages and increase the available cell source for application to bone tissue engineering therapies. This review article critically examines the various experimental strategies used to direct the differentiation of ESC, BMMSC, UCB-MSC, ADSC, MDSC, and DPSC towards osteogenic lineages and their potential applications in tissue engineering, particularly in the regeneration of bone.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

review paper: embryonic stem cell and osteogenic differentiation

bone tissue engineering has been one of the most promising areas of research, providing a potential clinical application to cure bone defects. recently, various stem cells, including embryonic stem cells (escs), bone marrow-derived mesenchymal stem cells (bm-mscs), umbilical cord blood-derived mesenchymal stem cells (ucb-mscs), adipose tissue-derived stem cells (adscs), muscle-derived stem cell...

متن کامل

Differentiation of Mouse Embryonic Stem Cell into Insulin-Secreting Cell

Purpose: Differentiation of mouse embryonic stem cells into Insulin secreting endocrine cells. Materials and Methods: In this study, Royan B1 mouse embryonic stem cell (derived from C57BL/6 mouse) were used. In directed differentiation method, embryonicstem cells after embryoid bodies formation were differentiated into insulin secreting cells. Nestin positive cells were obtained after culture ...

متن کامل

The Effect of Human Platelet-Rich Plasma on Adipose-Derived Stem Cell Proliferation and Osteogenic Differentiation

Background: The cultured mesenchymal stem cells (MSC) have been used in many clinical trials however, there are still some concerns about the cultural conditions. One concern is related to the use of FBS as a widely used xenogeneic supplement in the culture system. Human platelet-rich plasma (hPRP) is a candidate replacement for FBS. In this study, the effect of hPRP on MSC proliferation and os...

متن کامل

Review Paper: Adipose Tissue, Adipocyte Differentiation, and Variety of Stem Cells in Tissue Engineering and Regeneration

Human adipose tissue represents an abundant, practical and appealing source of donor tissue for autologous cell replacement. Recent findings have shown that stem cells within the stromalvascular fraction of adipose tissue display a multilineage developmental potential. Adipose tissue-derived stem cells can be differentiated towards adipogenic, osteogenic, chondrogenic,myogenic and neurogenic li...

متن کامل

Enhancing osteogenic differentiation of mouse embryonic stem cells by nanofibers.

Controlled differentiation of embryonic stem cells (ESC) is necessary to their use as a cell source for tissue engineering or regeneration. To date, most studies have concentrated on chemical cues to direct ESC differentiation. However, during normal embryonic development, multiple factors beyond chemical cues play a role, including the extracellular matrix (ECM) in bone development. In this st...

متن کامل

Biomineralized matrix-assisted osteogenic differentiation of human embryonic stem cells.

The physical and chemical properties of a matrix play an important role in determining various cellular behaviors, including lineage specificity. We demonstrate that the differentiation commitment of human embryonic stem cells (hESCs), both in vitro and in vivo, can be solely achieved through synthetic biomaterials. hESCs were cultured using mineralized synthetic matrices mimicking a calcium ph...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره 13  شماره 2

صفحات  79- 84

تاریخ انتشار 2016-05

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023