نتایج جستجو برای: acetaminophen

تعداد نتایج: 10385  

Journal: :anesthesiology and pain medicine 0
shun muramatsu division of cancer pathophysiology, national cancer center research institute, tokyo, japan seiji shiraishi division of cancer pathophysiology, national cancer center research institute, tokyo, japan kanako miyano division of cancer pathophysiology, national cancer center research institute, tokyo, japan yuka sudo division of cancer pathophysiology, national cancer center research institute, tokyo, japan; division of molecular pathology and metabolic disease, department of pharmaceutical sciences, tokyo university of science, noda, japan akiko toda pharmacokinetics and bioanalysis center, shin nippon biomedical laboratories, ltd., wakayama, japan masayuki mogi pharmacokinetics and bioanalysis center, shin nippon biomedical laboratories, ltd., wakayama, japan

conclusions these data suggest that am404’s concentration-time profile in the brain is similar to those of acetaminophen and its other metabolites. measurement of blood acetaminophen concentration seems to reflect the concentration of the prospective bioactive substance, am404. results the maximum plasma concentrations of acetaminophen and am404 in the rat brain were 15.8 µg/g and 150 pg/g, res...

ژورنال: بیهوشی و درد 2022

Background: Pain relief after C/S is very important. Acetaminophen is one of the most common drugs to control post-operative pain. Due to the fact that Acetaminophen IV should be injected several times a day for patients, to save time, manpower and cost, it is recommended to inject intravenous Acetaminophen in 24-hour drip. Therefore, this study was designed and performed to compare Acetaminoph...

2015
Laura James Ke Yan Lisa Pence Pippa Simpson Sudeepa Bhattacharyya Pritmohinder Gill Lynda Letzig Gregory Kearns Richard Beger Gustavo Batista Menezes

Metabolomics approaches have enabled the study of new mechanisms of liver injury in experimental models of drug toxicity. Disruption of bile acid homeostasis is a known mechanism of drug induced liver injury. The relationship of individual bile acids to indicators of oxidative drug metabolism (acetaminophen protein adducts) and liver injury was examined in children with acetaminophen overdose, ...

2015
Yanli Zhao Jerold S. Harmatz Carol R. Epstein Yukako Nakagawa Chie Kurosaki Tetsuro Nakamura Takumi Kadota Dennis Giesing Michael H. Court David J. Greenblatt

AIMS The antiviral agent favipiravir is likely to be co-prescribed with acetaminophen (paracetamol). The present study evaluated the possiblility of a pharmacokinetic interaction between favipiravir and acetaminophen, in vitro and in vivo. METHODS The effect of favipivir on the transformation of acetaminophen to its glucuronide and sulfate metabolites was studied using a pooled human hepatic ...

Journal: :The Journal of the American Board of Family Practice 1998
G L Maze M Lee

Acetaminophen is a popular over-the-counter analgesic used for headaches and minor musculoskeletal pains. Most persons taking therapeutic doses of acetaminophen experience no side effects. \¥hen taken in greater than the recommended dosage, however, acetaminophen can cause serious complications, including liver and renal failure as well as death. l This outcome is especially evident in those wh...

Journal: :Rhode Island medical journal 2013
Jay H Levin Margaret M Gordon Frederick W Burgess

BACKGROUND Prescription opioid-acetaminophen products account for the majority of cases of acetaminophen-related acute liver failure in the United States. We sought to examine the frequency of opioid-acetaminophen overuse at the Providence VA Medical Center and improve the quality and safety of opioid-acetaminophen prescription practices in a system employing electronic health records and e-pre...

Journal: :Molecular pharmacology 2005
Jun Gu Huadong Cui Melissa Behr Li Zhang Qing-Yu Zhang Weizhu Yang Jack A Hinson Xinxin Ding

Acetaminophen overdose causes toxicity in liver and extrahepatic tissues. Although it is well established that cytochrome P450 enzymes play a critical role in the metabolic activation of acetaminophen, it is not yet clear whether acetaminophen toxicity in extrahepatic tissues is a consequence of hepatic biotransformation. The aim of this study was to determine whether extrahepatic acetaminophen...

2016
Sammy Saab Peter G. Konyn Matthew R. Viramontes Melissa A. Jimenez Jonathan F. Grotts Wally Hamidzadah Veronica P. Dang Negin L. Esmailzadeh Gina Choi Francisco A. Durazo Mohamed M. El-Kabany Steven-Huy B. Han Myron J. Tong

Background and Aims: Unintentional acetaminophen overdose remains the leading cause of acute liver failure in the United States. Patients with underlying liver disease are at higher risk of poor outcomes from acetaminophen overdose. Limited knowledge of acetaminophen may be a preventable contributor to elevated rates of overdose and thus acute liver failure. The purpose of this study is to asse...

2017
Ryan G Thomas Brenda M Rivera Reyes Benjamin M Gaston Nelki B Rivera Acosta Ilya R Bederman Laura A Smith Morgan T Sutton Benlian Wang John F Hunt Tracey L Bonfield

BACKGROUND An association of acetaminophen use and asthma was observed in the International Study of Asthma and Allergies in Childhood study. However there are no clear mechanisms to explain an association between acetaminophen use and immunologic pathology. In acidic conditions like those in the stomach and inflamed airway, tyrosine residues are nitrated by nitrous and peroxynitrous acids. The...

2016
L. de Jong D.G. Knapen T.H. Oude Munnink M.J. Henstra T.F. Veneman

INTRODUCTION Serum concentrations of acetaminophen are measured to predict the risk of hepatotoxicity in cases of acetaminophen overdose and to identify acetaminophen use in patients with acute liver injury without a known cause. The acetaminophen concentration determines if treatment with N-acetyl cysteine, the antidote for acetaminophen poisoning, is warranted. DESCRIPTION A 49-year-old wom...

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