Acetaminophen is a commonly used analgesic. However, an overdose of acetaminophen causes severe hepatotoxicity via depletion of hepatic glutathione. Here, we investigated the protective effects of sake lees hydrolysate against acetaminophen-induced hepatotoxicity in mice. Sake lees hydrolysate was administered orally to ICR mice for seven days. Six hours after acetaminophen treatment, the mice ...

    Background & Objective:  Acetaminophen is known as the most common agent which causes hepatic and renal toxicity in human and experimental animals at supra-therapeutic doses. The current study investigated the protective effects of Descurainia sophia seed extract on the acetaminophen-induced nephrotoxicity markers in male mice.  Materials & Methods:  Experimental male mice (n=60, Swiss alb...

background acetaminophen exposure might be associated with increasing risk of asthma prevalence and other atopic disorders over recent decades. the present study aimed to investigate the association between acetaminophen exposure and the risk of developing childhood asthma. methods a case - control study was undertaken between march and september 2010 in urmia district north west of iran. subje...

BACKGROUND Postoperative pain control (especially, after adenotonsillectomy) has a very important effect on recovery time, hospitalization duration, hemodynamic disorders, bleeding, nausea, vomiting and medical costs. OBJECTIVES The aim of this study was to investigate and compare the effects of intravenous and rectal acetaminophen on controlling post-adenotonsillectomy pain in children, and ...

Acetaminophen is a phenol with antioxidant properties, but little is known about its actions on the mammalian myocardium and coronary circulation. We studied isolated, perfused guinea pig hearts, and tested the hypothesis that acetaminophen-treated hearts would be protected during ischemia-reperfusion. Acetaminophen concentrations in the range of 0.3-0.6 mmol/l caused modest but significant (P ...

• Objective: To assess and compare practicing gastroenterologist and primary care physician (PCP) knowledge of risk factors for, clinical management of, and attitudes toward liver transplantation for acetaminophen hepatotoxicity. • Participants and setting: 333 PCPs and 64 gastroenterologists practicing in Michigan. • Outcome measures: Knowledge of risk factors and management were measured by s...

Acetaminophen is a leading cause of acute liver failure (ALF). Genetic differences might predispose some individuals to develop ALF. In this exploratory study, we evaluated genotype frequency differences among patients enrolled by the ALF Study Group who had developed ALF either intentionally from a singletime-point overdose of acetaminophen (n = 78), unintentionally after chronic high doses of...

In this study, IP administration of acetaminophen and its half-life were investigated. Acetaminophen as an analgesic drug ordinarily is used in tablets or syrup form. Therefore, there is no report about administration of acetaminophen through injection. Acetaminophen in ED50 dose (200 mg/kg) was injected into the animals intraperitoneally, and its analgesic effect was investigated by formalin t...

The epidemiologic association between acetaminophen use and asthma prevalence and severity in children and adults is well established. A variety of observations suggest that acetaminophen use has contributed to the recent increase in asthma prevalence in children: (1) the strength of the association; (2) the consistency of the association across age, geography, and culture; (3) the dose-respons...

Overdoses of acetaminophen cause hepato-renal oxidative stress. The present study was undertaken to investigate the protective effect of a 43 kDa protein isolated from the herb Cajanus indicus, against acetaminophen-induced hepatic and renal toxicity. Male albino mice were treated with the protein for 4 days (intraperitoneally, 2 mg/kg body wt) prior or post to oral administration of acetaminop...