Cerebellar pilocytic Astrocytoma is a benign tumor, acounts for 80% of all cerebellar Astrocytoma, and has a relatively good prognosis. This tumor usually presents with Ataxia and in the case of hydrocephaly with raised intracranial pressure signs such as headeach, and vomiting. Treatment of this tumor is complete resection and if hydrocephally is present V.P. shunt should be inserted. In the c...

In most instances, gemistocytic astrocytoma progresses to anaplastic astrocytoma at the time of recurrence. Here, we report an unusual case where a gemistocytic astrocytoma converted to a more benign fibrillary histology after temozolomide/radiation therapy. We present the case of a 26-year-old woman with a history of fibrillary astrocytoma that was followed over a span of eight years and under...

Astrocytoma is one of the most common types of brain tumor, which is histologically and clinically classified into four grades (I-IV): I (pilocytic astrocytoma), II (diffuse astrocytoma), III (anaplastic astrocytoma), and IV (glioblastoma multiforme). A higher grade astrocytoma represents a worse prognosis and is more aggressive. In this study, we compared the differential proteome profile of a...

BACKGROUND The prognosis of human astrocytoma is poor, and the molecular alterations underlying its pathogenesis still needed to be elucidated. Nucleolar and spindle associated protein 1 (NUSAP1) was observed in several types of cancers, but its role in astrocytoma remained unknown. METHODS The expression of NUSAP1 in astrocytoma cell lines and tissues were measured with western blotting and ...

BACKGROUND AND PURPOSE Pilocytic astrocytomas, the most common posterior fossa tumors in children, are characterized by KIAA1549-BRAF fusions and shows excellent 5-year survival rates. Pilocytic astrocytoma with gangliocytic differentiation, a recently defined pilocytic astrocytoma variant that includes glial and neuronal elements similar to a ganglioglioma, may be distinguished from a classic ...

chemokines are biologically active peptides involved in the pathogenesis of various pathologies including brain malignancies. they are amongst primitive regulators of the development of immune responses against malignant glial tumors. the present study aimed to examine the expression of cc chemokines in anaplastic astrocytoma and glioblastoma multiform patients at both mrna and protein levels. ...

BACKGROUND Astrocytoma, a common and highly malignant type of brain tumor, is associated with poor overall survival despite advances in surgical treatment, radiotherapy, and chemotherapy. The nuclear transcription factor Fli-1 has been shown to increase cellular proliferation and tumorigenesis in many types of cancer; however, previous reports have not described a correlation between clinical o...

Bone metastasis from a spinal cord astrocytoma has been reported only twice in the English medical literature. It is generally known that bone metastasis is found after the initial diagnosis with/without intervening surgery rather than being found at the time of the diagnosis of astrocytoma. The purpose of this article is to report for the first time a case of concurrent bone metastasis from a ...

High-grade astrocytomas are invariably deadly and minimally responsive to therapy. Pten is frequently mutated in aggressive astrocytoma but not in low-grade astrocytoma. However, the Pten astrocytoma suppression mechanisms are unknown. Here we introduced conditional null alleles of Pten (Pten(loxp/loxp)) into a genetically engineered mouse astrocytoma model [TgG(deltaZ)T121] in which the pRb fa...