participation in clinical trials can be useful for the health of a person, in who it is conducted, but it does not have to be - it can even be harmful. therefore, primary motive to accept such risk is humanity and human wish to contribute to the progress of medicine; this is expressed by personal consent. the consent, however, can be an expression of personal humanity, and for this, it is not l...

clinical trial committee (ctc) has been established in food and drug organization (fdo), in 2003 to assure efficacy and safety of all types of medicinal products which are meant to be registered in iran drug list and/or obtain market authorization.all clinical trial files, meeting minutes and databases in ctc secretariat in fdo were reviewed. relevant information and data extracted, analyzed an...

stroke is an important cause of death in the world and disability world‑wide especially in developed countries. following acute phase of stroke, some procedures and medical treatment such as thrombolytic agents has been recommended; nevertheless many patients have enduring deficits. thus, there is a realistic need to develop treatment strategies for reducing neurological deficits. however, the ...

abstract background: acute bronchiolitis is the most common form of lower respiratory tract infection in infancy. there are numerous contradictory reports regarding the efficacy of nebulized bronchodilators in the management of infants with acute bronchiolitis. this study was designed to compare the efficacy of nebulized epinephrine with salbutamol for treatment of the disease. methods: in a ra...

considering the importance of randomized clinical trials (rcts) in the evidence-based approach, the objective of this study was critical appraisal of reporting rcts in iranian dental journals.after adequate searching, 113 rct articles published during 2003-2010 were reviewed for quality of reporting with the consort scale. the quality of each paper was assessed on 20.although statistical analys...

there are evidences that statins have anti-inflammatory effects beyond their cholesterol lowering properties. the study was conducted to assess the effects of atorvastatin on asthma as an inflammatory disease. patients with moderate to severe asthma were entered this randomized, double blind, crossover clinical trial. the impact of oral atorvastatin (10 mg/day) on the lung function of normolipi...

obtaining informed consents is one of the most fundamental principles in conducting a clinical trial. in order for the consent to be informed, the patient must receive and comprehend the information appropriately. complexity of the consent form is a common problem that has been shown to be a major barrier to comprehension for many patients. the objective of this study was to assess the readabil...

ethical consideration is a basic requirement for design of randomized clinical trials. the purpose of this study was to assess whether reports of iranian dental clinical trials complied with the requirements of the ethical principles of human research.in this retrospective observational study electronic search was performed to identify all dental clinical trials published between 2001 and 2011....

free radicals are produced continuously in the cells as part of normal cellular function, however excess production might play a role in pathophysiology of many disease conditions, including cancer, alzheimer's disease, atherosclerosis and some of the drug-induced toxicity. many basic research studies and observational epidemiologic studies in human suggest that antioxidants can prevent oxidati...

background: the study aim was to reports detailed characteristics of nutrition research in field of diabetes, and recognize knowledge gap in nutrition science in diabetes in iran. methods: online databases of pubmed, web of science and scopus as well as national databases including sid, iranmedex, and magiran were searched up to 2015 to identify eligible articles. finally, 378 articles were inc...