background: primary cultures of embryonic neurons have been used to introduce a model of neurons in physiological and pathological conditions. however, age-related cellular events limit this method as an optimal model in adult neurodegenerative diseases studies. besides, short-interval changing media in previous cultures decreases the effectiveness of this model. as an example of this matter, w...

objective(s):to determine the effect of acetylcholine (ach), pilocarpine, and atropine on pain evoked responses of pain excited neurons (pen) and pain inhibited neurons (pin) in hippocampal ca3 region of morphine addicted rats. materials and methods:female wistar rats, weighing between 230-260 g were used in this study. morphine addicted rats were generated by subcutaneous injection of increasi...

introduction: the septal area is an important telencephalic center that plays a prominent role in the learning, emotional sexual behaviour processes and autonomic functions. this area contains two main divisions; lateral (ls) and medial (ms), that receive numerus afferents from hippocampal formation. this study compares, quantitatively distributional pattern of the afferent neurons to these two...

introduction: many studies have shown that amygdala kindling produces synaptic potentiation by induction of changes in the neuronal electrophysiological properties and inward currents both in epileptic focus and in the areas which are in connection with the epileptic focus and have important role in seizure development and progression such as hippocampal ca1 region. however, cellular mechanisms...

Objective(s):To determine the effect of acetylcholine (ACh), pilocarpine, and atropine on pain evoked responses of pain excited neurons (PEN) and pain inhibited neurons (PIN) in hippocampal CA3 region of morphine addicted rats. Materials and Methods:Female Wistar rats, weighing between 230-260 g were used in this study. Morphine addicted rats were generated by subcutaneous injection of increasi...

objective(s):the present study investigated the effect of long-term mild cerebral hypoperfusion induced by permanent unilateral (right) common carotid artery occlusion (uco) on the dorsal hippocampal neurons in rats. materials and methods:sixty four male sprague-dawley rats aged 4 months were divided into two groups of sham and uco. these two groups were further divided into 4 sets of histopath...

objective(s): crocin influences many biological functions including memory and learning. the present study was aimed to investigate the effects of crocin on learning and memory impairments in streptozotocine-induced diabetic rats. materials and methods: diabetes was induced by intraperitoneal (ip) injection of streptozotocin (stz, 45 mg/kg). transfer latency (tl) paradigm in elevated plus-maze ...

introduction mdma or ecstasy is a derivative of amphetamines used mostly by young people worldwide. although the acute effects of this drug are known, the effect of chronic administration is not well studied. therefor the aim of this study was to determine the effects of repeated (long term) administration of mdma on rats' memory and their hippocampal cell density. method: young adult male...

this study was conducted to evaluate the effect of soy milk on serum 17- β estradiol level and number of neurons in cerebral cortex and hippocampus as well as determination of the ratio of neurons in cortical and hippocampal regions in neonatal ovariectomized rats. thirty female rats (one day old) were divided into six groups of five. at day 7, ovariectomy surgery was performed in four groups a...

introduction: antibiotic supplements are regularly used in neuronal culture media to control contamination however, they can interfere with the neuronal excitability and affect electrophysiological properties. therefore, in this study, the effect of penicillin/streptomycin supplements on the spontaneous electrophysiological activity of hippocampal pyramidal neurons was examined. methods: electr...