نتایج جستجو برای: memantine

تعداد نتایج: 1420  

Journal: :modares journal of medical sciences: pathobiology 2014
nahid sarahian hedayat sahraei homeira zardooz hengameh alibeik bahareh sadeghi

objective: in the present study, we examined the effects of memantine administration within the nucleus accumbens on the alterations in brain and adrenal volumes and weight ratios induced by stress from electric foot shock. methods: a group of mice received various doses of memantine (0.1, 0.5 and 1 mg/kg) prior to induction of stress. another group underwent intra-accumbal cannulation after an...

Journal: :iranian journal of basic medical sciences 0
sima seifabadi applied physiology research center, cardiovascular research institute, department of physiology, isfahan university of medical sciences, isfahan, iran golnaz vaseghi isfahan cardiovascular research center, cardiovascular research institute, isfahan university of medical sciences, isfahan, iran shaghayegh haghjooy javanmard applied physiology research center, cardiovascular research institute, department of physiology, isfahan university of medical sciences, isfahan, iran elham omidi applied physiology research center, cardiovascular research institute, department of physiology, isfahan university of medical sciences, isfahan, iran mohammadhasan tajadini applied physiology research center, cardiovascular research institute, department of physiology, isfahan university of medical sciences, isfahan, iran bahareh zarrin applied physiology research center, cardiovascular research institute, department of physiology, isfahan university of medical sciences, isfahan, iran

objective(s):breast cancer is an important leading cause of death from cancer. stathmin and tau proteins are regulators of cell motility, and their overexpression is associated with the progression and bad prognosis of breast cancer. memantine, an n-methyl-d-aspartate (nmda) receptor antagonist, is the potential inhibitor of tau protein in neurons. this study determines the effect of memantine ...

Journal: :Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology 2012
Cédric Annweiler François R Herrmann Bruno Fantino Bernard Brugg Olivier Beauchet

OBJECTIVE To determine whether treatment with memantine plus vitamin D is more effective than memantine or vitamin D alone in improving cognition among patients with Alzheimer disease (AD). METHODS We studied 43 white outpatients (mean 84.7 ± 6.3 years; 65.1% women) with a new diagnosis of AD, who had not taken anti-dementia drugs or vitamin D supplements. We prescribed memantine alone (n = 1...

Journal: :Fundamental & clinical pharmacology 2015
Yu-Wen Chen Chong-Chi Chiu Kuo-Sheng Liu Ching-Hsia Hung Jhi-Joung Wang

Although memantine blocks sodium currents and produces local skin anesthesia, spinal anesthesia with memantine is unknown. The purpose of the study was to evaluate the local anesthetic effect of memantine in spinal anesthesia and its comparison with a widely used local anesthetic lidocaine. After intrathecally injecting the rats with five doses of each drug, the dose-response curves of memantin...

Aim: The aim of this study is to evaluate the effect of memantine on negative symptoms in patients with schizophrenia and schizoaffective. Methods: This is a double- blind randomized clinical trial. 58 patients participated in the study, 29 patients were randomly assigned to the memantine group and 29 patients to the placebo group. For assessing negative signs, and we used scale for the assess...

زردوز, حمیرا, سراحیان, ناهید, صادقی, بهاره, صحرایی, هدایت,

Background and Objective: Memantine is a glutamate N-Methyl-D-Aspartate (NMDA) receptor antagonist with low receptor binding affinity which is currently used in moderate to severe Alzheimer’s disease. So far, the effect of memantine on stress system has not been investigated. This study focused on the effects of both peripheral and intra-accumbal memantine administration on plasma corticosteron...

2012
Thomas L. Schwartz Umar A. Siddiqui Shafi Raza

Objective. Glutamate, an excitatory neurotransmitter in the central nervous system (CNS), may play a role in the development of anxiety. Memantine partially blocks N-methyl-D-aspartate (NMDA) receptors' glutamate channels located in the CNS. This paper evaluates memantine as an augmentation therapy for treatment of anxiety. Methods. 15 consecutive partially responding anxious patients were trea...

Bahareh Zarrin Elham Omidi, Golnaz Vaseghi, Mohammadhasan Tajadini Shaghayegh Haghjooy Javanmard, Sima Seifabadi,

Objective(s):Breast cancer is an important leading cause of death from cancer. Stathmin and tau proteins are regulators of cell motility, and their overexpression is associated with the progression and bad prognosis of breast cancer. Memantine, an N-methyl-D-aspartate (NMDA) receptor antagonist, is the potential inhibitor of tau protein in neurons. This study determines the effect of memantine ...

Introduction: Memantine as N-Methyl-D-aspartic acid (NMDA) receptor antagonist is used in some neurological disorders. It has been reported that memantine has modulatory effects on the somatosensory information processing in healthy subjects. This study investigated the effect of memantine on electrophysiological properties of barrel cortex neurons in male rats. Methods: Single unit recording ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2014
Erinn S Gideons Ege T Kavalali Lisa M Monteggia

Ketamine is an NMDA receptor (NMDAR) antagonist that elicits rapid antidepressant responses in patients with treatment-resistant depression. However, ketamine can also produce psychotomimetic effects that limit its utility as an antidepressant, raising the question of whether the clinically tolerated NMDAR antagonist memantine possesses antidepressant properties. Despite its similar potency to ...

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