expressions of cd11a, cd11b, and cd11c integrin proteins in rats with myocardial hypertrophy

نویسندگان

lingmin mu morphological laboratory of xinxiang medical university, xinxiang, henan 453003, p. r. china

changqin jing life science and technology department, xinxiang medical university, xinxiang, henan 453003, p. r. china

zhikun guo key open laboratory for tissue regeneration of henan providence, xinxiang, henan 453003, p. r. china

چکیده

objective(s):to examine the expressions of cd11a, cd11b, and cd11c integrins in the myocardial tissues of rats with isoproterenol-induced myocardial hypertrophy. this study also provided morphological data to investigate the signal transduction mechanisms of myocardial hypertrophy and reverse it. materials and methods: a myocardial hypertrophy model was established by subcutaneously injecting isoprenaline in healthy adult sprague-dawley rats. myocardial tissues were obtained, embedded in conventional paraffin, sectioned, and stained with hematoxylin. pathological changes in myocardial tissues were then observed. the expressions and distributions of cd11a, cd11b, and cd11c integrins were detected by immunohistochemistry. changes in the mrna expressions of cd11a, cd11b, and cd11c in the myocardial tissues of rats were detected by rt-pcr. image analysis software was used to determine the expressions of cd11a, cd11b, and cd11c integrins quantitatively. results: immunohistochemical results showed that the positive expressions of cd11a, cd11b, and cd11c integrins increased significantly in the experimental group compared with those in the control group. the mrna expressions of cd11a, cd11b, and cd11c in the myocardial tissues of rats were consistent with the immunohistochemical results. conclusion: the increase in the protein expressions of cd11a, cd11b, and cd11c integrins may have an important role in the occurrence and development of myocardial hypertrophy.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Expressions of CD11a, CD11b, and CD11c integrin proteins in rats with myocardial hypertrophy

Objective(s):To examine the expressions of CD11a, CD11b, and CD11c integrins in the myocardial tissues of rats with isoproterenol-induced myocardial hypertrophy. This study also provided morphological data to investigate the signal transduction mechanisms of myocardial hypertrophy and reverse it. Materials and Methods: A myocardial hypertrophy model was established by subcutaneously injecting i...

متن کامل

Expressions of CD11a, CD11b, and CD11c integrin proteins in rats with myocardial hypertrophy

OBJECTIVES To examine the expressions of CD11a, CD11b, and CD11c integrins in the myocardial tissues of rats with isoproterenol-induced myocardial hypertrophy. This study also provided morphological data to investigate the signal transduction mechanisms of myocardial hypertrophy and reverse it. MATERIALS AND METHODS A myocardial hypertrophy model was established by subcutaneously injecting is...

متن کامل

Expression of N-cadherin proteins in myocardial hypertrophy in rats

The aim of the present study was to examine the expression of N-cadherin in the myocardial tissues of isoproterenol-induced myocardial hypertrophy in rats. In addition, the present study provided morphological data to investigate the signal transduction mechanisms of myocardial hypertrophy and reverse myocardial hypertrophy. A myocardial hypertrophy model was established by subcutaneously injec...

متن کامل

Aggravated Lyme carditis in CD11a-/- and CD11c-/- mice.

CD18 hypomorph mice expressing reduced levels of the common beta2 integrin chain develop aggravated Lyme carditis, compared to that developed by wild-type (WT) mice, upon infection with the spirochete Borrelia burgdorferi. The enhancement of Lyme carditis in these mice is characterized by increased macrophage infiltration, correlating with augmented expression of the monocyte/macrophage chemoat...

متن کامل

The Effect of Aerobic Training on expression of some indices of myocardial hypertrophy and atrophy in rats

Background: Protein synthesis and degradation are dynamically regulated processes that to control the accretion or loss of muscle mass. However, the mechanisms responsible exercise-induced heart hypertrophy remains elusive. The aim of this study was to investigate the effect of aerobic training on expression of some indices of myocardial hypertrophy and atrophy in male rats. Materials and Meth...

متن کامل

Surfactant protein D regulates the cell surface expression of alveolar macrophage beta(2)-integrins.

The beta(2)-integrin receptors (CD11a/CD18, CD11b/CD18, and CD11c/CD18) are expressed on the surface of alveolar macrophages and are important for the phagocytic clearance of pathogens. In the present study, we demonstrate that surfactant protein D (SP-D) modulates surface expression of CD11b and CD11c, but not CD11a or CD18, on alveolar macrophages. While cell surface receptors were reduced, C...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of basic medical sciences

جلد ۱۷، شماره ۱۱، صفحات ۸۷۴-۸۷۸

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023