Simplex Virus Type 1 Expressing the Prodrug-Activating Brain Tumor Oncolysis with Replication-Conditional Herpes

اسناد مشابه

• Definition of Herpes Simplex Virus Type 1 Helper Activities for Adeno-Associated Virus Early Replication Events

  سند علمی۲۰۰۹PLoS PathogensNathalie Alazard-Dany, Armel Nicolas, Aurélie Ploquin, Regina Strasser

  The human parvovirus Adeno-Associated Virus (AAV) type 2 can only replicate in cells co-infected with a helper virus, such as Adenovirus or Herpes Simplex Virus type 1 (HSV-1); whereas, in the absence of a helper virus, it establishes a latent infection. Previous studies demonstr

• The herpes simplex virus type 1 vhs-UL41 gene secures viral replication by temporarily evading apoptotic cellular response to infection: Vhs-UL41 activity might require interactions with elements of cellular mRNA degradation machinery.

  سند علمی۲۰۰۶Journal of virologyAri Barzilai, Ifaat Zivony-Elbom, Ronit Sarid, Eran Noah

  We have previously shown that herpes simplex virus type 1 (HSV-1) infection is associated with early destabilization/degradation of infected cell mRNAs and consequent shutoff of host protein synthesis by the activity of the virion-associated host shutoff (vhs) UL41 protein. Wild-

• Specific viral antigens in rat cells transformed by herpes simplex virus type 2 and in rat tumors induced by inoculation of transformed cells.

  سند علمی۱۹۸۰Cancer researchJ C Macnab, L Visser, A T Jamieson, J Hay

  A rat cell line, RE1, oncogenically transformed by a herpes simplex virus type 2 ts mutant (ts 1), has been demonstrated to contain herpes simplex virus type 2-specific thymidine kinase activity, as have two of four tumors induced in rats by inoculation of these transformed cells

• Comparison of genetically engineered herpes simplex viruses for the treatment of brain tumors in a scid mouse model of human malignant glioma.

  سند علمی۱۹۹۵Proceedings of the National Academy of Sciences of the United States of AmericaR Chambers, G Y Gillespie, L Soroceanu, S Andreansky

  Genetically engineered viruses and viral genes inserted into retroviral vectors are increasingly being considered for experimental therapy of brain tumors. A primary target of these viruses and vectors is human gliomas, the most frequently occurring primary human brain tumor. To

• Herpes simplex virus type 1 latency-associated transcripts suppress viral replication and reduce immediate-early gene mRNA levels in a neuronal cell line.

  سند علمی۱۹۹۸Journal of virologyN Mador, D Goldenberg, O Cohen, A Panet

  During herpes simplex virus type 1 (HSV-1) latent infection in human dorsal root ganglia, limited viral transcription, which has been linked to HSV-1 reactivation ability, takes place. To study the involvement of this transcription in HSV-1 replication in neuronal cells and conse

• A Novel Oncolytic Herpes Simplex Virus Type 2 Has Potent Anti-Tumor Activity

  سند علمی۲۰۱۴PloS oneQian Zhao, Wen Zhang, Zhifeng Ning, Xiufen Zhuang

  Oncolytic viruses are promising treatments for many kinds of solid tumors. In this study, we constructed a novel oncolytic herpes simplex virus type 2: oHSV2. We investigated the cytopathic effects of oHSV2 in vitro and tested its antitumor efficacy in a 4T1 breast cancer model.