cyclophosphamide (cp) is extensively used as an antineoplastic agent for the treatment of various cancers, as well as an immunosuppressive agent. however, despite its wide spectrum of clinical uses, cp is known to cause several adverse effects including reproductive toxicity. crataegus monogyna is one of the oldest pharmaceutical plants that have been shown to be cytoprotective by scavenging fr...

the differential activation of th1 and th2 cells using mafosfamide (mafo) was investigated in vitro in a rat model of alloreactivity. the results of this study are compatible with the hypothesis that mafo, like its parent compound cyclophosphamide, is selectively active against th2-type t-helper cells when administered at low doses (

background: one of the affecting factors in disturbance process of spermatogenesis is chemotherapeutic-induced oxidative stress resulted from cyclophosphamide (cp) treatment which leads to diminished sperm quality via interference in spermatogenesis process. objective: this study was conducted to investigate the effects of ethyl pyruvate (ep) in reducing the cp-induced side effects on reproduct...

Background: Cylophosphamide is used alone or in combination with other drugs for treatment of neoplastic diseases. Hemorrhagic cystitis is a major potential toxicity and dose limiting side effect of cyclophosphamide. The aim of this study was to evaluate the effects of lycopene compared with some antioxidants for the prevention of cyclophosphamide induced hemorrhagic cystitis in rats. Methods: ...

the study was designed with an aim to evaluate the protective effects of reduced glutathione on cyclophosphamide induced lipid peroxidation and also changes in cholesterol content. goat liver and white new zealand rabbit were used as lipid source for the models. lipid peroxidation study was performed by measuring the malondialdehyde, 4-hydroxy-2-nonenal, reduced glutathione and nitric oxide con...

background: cylophosphamide is used alone or in combination with other drugs for treatment of neoplastic diseases. hemorrhagic cystitis is a major potential toxicity and dose limiting side effect of cyclophosphamide. the aim of this study was to evaluate the effects of lycopene compared with some antioxidants for the prevention of cyclophosphamide induced hemorrhagic cystitis in rats.   methods...

Background: Cyclophosphamide as an alkalizing and cytotoxic agent contributes in treatment of different kinds of cancer. It can pass the blood-brain barrier. Linking two strains of DNA in cell nucleus and breaking the inner and outer strain linkages and inhibiting RNA synthesis and as a consequence, inhibiting protein synthesis, cyclophosphamide demonstrates severe pharmacological side effects ...