ویراساینس.
سند علمی

Intrauterine programming of physiological systems: causes and consequences.

Abigail L Fowden, Dino A Giussani, Alison J Forhead

چکیده

The intrauterine conditions in which the mammalian fetus develops have an important role in regulating the function of its physiological systems later in life. Changes in the intrauterine availability of nutrients, oxygen, and hormones program tissue development and lead to abnormalities in adult cardiovascular and metabolic function in several species. The timing, duration, severity, and type of insult during development determines the specific physiological outcome. Intrauterine programming of physiological systems occurs at the gene, cell, tissue, organ, and system levels and causes permanent structural and functional changes, which can lead to overt disease, particularly with increasing age.

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    مقالهiranian journal of basic medical scienceskatayoun sedaghat endocrine physiology research center, research institute for endocrine sciences, shahid-beheshti university of medical sciences, tehran, iran., endocrine research center, research institute for endocrine sciences, shahid-beheshti university of medical sciences, tehran, iran, saleh zahediasl endocrine physiology research center, research institute for endocrine sciences, shahid-beheshti university of medical sciences, tehran, iran., endocrine research center, research institute for endocrine sciences, shahid-beheshti university of medical sciences, tehran, iran

    in mammals, the intrauterine condition has an important role in the development of fetal physiological systems in later life. suboptimal maternal environment can alter the regulatory pathways that determine the normal development of the fetus in utero, which in post-natal life ma