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مقاله

intrauterine programming

katayoun sedaghat endocrine physiology research center, research institute for endocrine sciences, shahid-beheshti university of medical sciences, tehran, iran., endocrine research center, research institute for endocrine sciences, shahid-beheshti university of medical sciences, tehran, iran, saleh zahediasl endocrine physiology research center, research institute for endocrine sciences, shahid-beheshti university of medical sciences, tehran, iran., endocrine research center, research institute for endocrine sciences, shahid-beheshti university of medical sciences, tehran, iran, asghar ghasemi endocrine physiology research center, research institute for endocrine sciences, shahid-beheshti university of medical sciences, tehran, iran., endocrine research center, research institute for endocrine sciences, shahid-beheshti university of medical sciences, tehran, iran

چکیده

in mammals, the intrauterine condition has an important role in the development of fetal physiological systems in later life. suboptimal maternal environment can alter the regulatory pathways that determine the normal development of the fetus in utero, which in post-natal life may render the individual more susceptible to cardiovascular or metabolic adult-life diseases. changes in the intrauterine availability of nutrients, oxygen and hormones can change the fetal tissue developmental regulatory planning, which occurs genomically and non-genomically and can cause permanent structural and functional changes in the systems, leading to diseases in early years of life and those that particularly become overt in adulthood. in this review we take a brief look at the main elements which program the fetal system development and consequently induce a crucial impact on the cardiovascular, nervous and hormonal systems in adulthood.

اسناد مشابه

  • Endocrine mechanisms of intrauterine programming.

    سند علمی۲۰۰۴ReproductionA L Fowden, A J Forhead

    Epidemiological findings and experimental studies in animals have shown that individual tissues and whole organ systems can be programmed in utero during critical periods of development with adverse consequences for their function in later life. Detailed morphometric analyses of

  • Intrauterine programming of physiological systems: causes and consequences.

    سند علمی۲۰۰۶PhysiologyAbigail L Fowden, Dino A Giussani, Alison J Forhead

    The intrauterine conditions in which the mammalian fetus develops have an important role in regulating the function of its physiological systems later in life. Changes in the intrauterine availability of nutrients, oxygen, and hormones program tissue development and lead to abnor

  • Intrauterine programming

    مقاله۲۰۱۵Iranian Journal of Basic Medical SciencesKatayoun Sedaghat, Saleh Zahediasl, Asghar Ghasemi

    In mammals, the intrauterine condition has an important role in the development of fetal physiological systems in later life. Suboptimal maternal environment can alter the regulatory pathways that determine the normal development of the fetus in utero, which in post-natal life ma

  • Intrauterine programming of ageing.

    سند علمی۲۰۱۰EMBO reportsOscar Fernandez-Capetillo

    Ageing is an unavoidable corollary to being alive; the most intuitive interpretation of ageing being that it is the consequence of progressive body degeneration. In agreement with this, current models propose that ageing occurs through a stepwise accumulation of DNA damage, which

  • Intrauterine programming

    سند علمی۲۰۱۵Iranian journal of basic medical sciencesKatayoun Sedaghat, Saleh Zahediasl, Asghar Ghasemi

    In mammals, the intrauterine condition has an important role in the development of fetal physiological systems in later life. Suboptimal maternal environment can alter the regulatory pathways that determine the normal development of the fetus in utero, which in post-natal life ma

  • Intrauterine programming of urinary calcium and magnesium excretion in children born to mothers with insulin dependent diabetes mellitus.

    سند علمی۲۰۰۵Archives of disease in childhood. Fetal and neonatal editionM Z Mughal, J A Eelloo, S A Roberts, S Sibartie

    BACKGROUND Offspring of diabetic rats have reduced urinary calcium and magnesium excretion compared with offspring of controls; these differences persist up to 16 weeks after birth, a time equivalent to young adulthood in humans. OBJECTIVES To test the hypothesis that urinary cal