ویراساینس.
سند علمی

Intrauterine programming of ageing.

Oscar Fernandez-Capetillo

چکیده

Ageing is an unavoidable corollary to being alive; the most intuitive interpretation of ageing being that it is the consequence of progressive body degeneration. In agreement with this, current models propose that ageing occurs through a stepwise accumulation of DNA damage, which ultimately limits the regenerative capacity of tissues. On the other hand, there is increasing evidence that fetal distress can influence the development of disease in adult life, a phenomenon known as 'intrauterine programming'. The extent to which an intrauterine exposure to DNA damage can compromise lifespan remains unclear. My group has recently generated a murine model of a human syndrome linked to defective DNA repair and observed that these animals age prematurely, but the accumulation of DNA damage is restricted mostly to the embryonic period. Here, I discuss the implications of this finding and propose that ageing can be influenced by fetal distress.

اسناد مشابه

  • Endocrine mechanisms of intrauterine programming.

    سند علمی۲۰۰۴ReproductionA L Fowden, A J Forhead

    Epidemiological findings and experimental studies in animals have shown that individual tissues and whole organ systems can be programmed in utero during critical periods of development with adverse consequences for their function in later life. Detailed morphometric analyses of

  • Intrauterine programming of physiological systems: causes and consequences.

    سند علمی۲۰۰۶PhysiologyAbigail L Fowden, Dino A Giussani, Alison J Forhead

    The intrauterine conditions in which the mammalian fetus develops have an important role in regulating the function of its physiological systems later in life. Changes in the intrauterine availability of nutrients, oxygen, and hormones program tissue development and lead to abnor

  • intrauterine programming

    مقالهiranian journal of basic medical scienceskatayoun sedaghat endocrine physiology research center, research institute for endocrine sciences, shahid-beheshti university of medical sciences, tehran, iran., endocrine research center, research institute for endocrine sciences, shahid-beheshti university of medical sciences, tehran, iran, saleh zahediasl endocrine physiology research center, research institute for endocrine sciences, shahid-beheshti university of medical sciences, tehran, iran., endocrine research center, research institute for endocrine sciences, shahid-beheshti university of medical sciences, tehran, iran

    in mammals, the intrauterine condition has an important role in the development of fetal physiological systems in later life. suboptimal maternal environment can alter the regulatory pathways that determine the normal development of the fetus in utero, which in post-natal life ma

  • Intrauterine programming

    مقاله۲۰۱۵Iranian Journal of Basic Medical SciencesKatayoun Sedaghat, Saleh Zahediasl, Asghar Ghasemi

    In mammals, the intrauterine condition has an important role in the development of fetal physiological systems in later life. Suboptimal maternal environment can alter the regulatory pathways that determine the normal development of the fetus in utero, which in post-natal life ma

  • Intrauterine programming

    سند علمی۲۰۱۵Iranian journal of basic medical sciencesKatayoun Sedaghat, Saleh Zahediasl, Asghar Ghasemi

    In mammals, the intrauterine condition has an important role in the development of fetal physiological systems in later life. Suboptimal maternal environment can alter the regulatory pathways that determine the normal development of the fetus in utero, which in post-natal life ma

  • Intrauterine programming of ageing

    مقاله‌ی دسترسی آزاد۲۰۰۹EMBO reportsOscarFernandez‐Capetillo