Weak Anti-inflammatory and Anti-cancer Properties of Saffron

Authors

  • Mohammad Hossein Heidari Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Mohammad Rostami-Nejad Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Mostafa Rezaei-Tavirani* Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Saeed Safari Proteomics Research Center, Department of Emergency Medicine, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Sina Rezaei-Tavirani Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Zahra Razzaghi Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract:

Background and objectives: Positive role of saffron in human health promotion has been investigated in widespread researches. Anticancer property, neuroprotection, protection of cardiovascular system and several positive properties are reported for saffron customers. The aim of this study was assessment of saffron weakness against light damage in rat retina. Methods: Gene profiles of control samples (C group) and light damage (L) groups were extracted from Gene Expression Omnibus (GEO) and compared with similar samples in the presence of saffron. The unprotected differentially expressed genes (DEGs) were evaluated via network analysis and pathway investigation.  The critical genes which were not protected by saffron were identified and discussed. Results: Numbers of 67 DEGs were investigated via protein-protein interaction (PPI) network analysis, pathway assessment, and action map investigation. Findings indicated that STAT1, JUN, FOS, and STAT3 were the crucial genes that were not protected by saffron against light damage in rat retina. Conclusion: It may be necessary that consumption of saffron require a suitable protocol to avoid from possible disadvantages; however, saffron is well known for its benefits in human nutrition. 

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Immunosuppressive, anti-inflammatory and anti-cancer properties of triptolide: A mini review

Objective: Triptolide, the active component of Tripterygium wilfordii Hook F has been used to treat autoimmune and inflammatory conditions for over two hundred years in traditional Chinese medicine. However, the processes through which triptolide exerts immunosuppression and anti-inflammation are not understood well. In this review, we discuss the autoimmune disorders and inflammatory condition...

full text

Immunoregulatory and anti-inflammatory properties of Crocus sativus (Saffron) and its main active constituents: A review

The medicinal uses of saffron, the dried stigmas of Crocus sativus L., have very long history in food coloring agent, and flavoring agent as well as traditional medicine for the treatment of several diseases. Crocus sativus is rich in carotenoids that affect immunity. This review summarizes the putative immunoregulatory effects of saffron and its active its derivatives including crocin, croceti...

full text

Anti-inflammatory, Analgesic and Antiulcer properties of Porphyra vietnamensis

Objectives: Aim of the present work was to investigate the anti-inflammatory, analgesic and antiulcer effects of red seaweed Porphyra vietnamensis (P. vietnamenis). Materials and Methods: Aqueous (POR) and alcoholic (PE) fractions were successfully isolated from P. vietnamenis. Further biological investigations were performed using a classic test of paw edema induced by carrageenan, writhing in...

full text

immunosuppressive, anti-inflammatory and anti-cancer properties of triptolide: a mini review

objective: triptolide, the active component of tripterygium wilfordii hook f has been used to treat autoimmune and inflammatory conditions for over two hundred years in traditional chinese medicine. however, the processes through which triptolide exerts immunosuppression and anti-inflammation are not understood well. in this review, we discuss the autoimmune disorders and inflammatory condition...

full text

A Systematic Review of Anti-malarial Properties, Immunosuppressive Properties, Anti-inflammatory Properties, and Anti-cancer Properties of Artemisia Annua

Artemisia annua belongs to the asteraceae family, indigenous to the mild climate of Asia. The aim of this study was to overview its anti-malarial properties, immunosuppressive properties, anti-inflammatory properties and anti-cancer properties. This systematic review was carried out by searching studies in PubMed, Medline, Web of Science, and IranMedex databases. The initial search strategy ide...

full text

Anti-carcinogenic and anti-angiogenic properties of the extracts of Acorus calamus on gastric cancer cells

Objective: Acorus calamus (A. calamus) has been used as a medicinal plant in Asia for its effects on digestive system for the last 2000 years. To investigate the anti-cancer activity of rhizome of A. calamus, the ethanolic and methanolic extracts and essential oil of the rhizome were prepared and their effects were assessed on human gastric cancer cell line (AGS). Materials and Methods: The via...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 7  issue 3

pages  35- 46

publication date 2020-07-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023