اثر گیاهان گل اشرفی، صبرزرد و کرچک بر روند التیام زخم‌های پوستی در موش صحرایی نر بالغ

Background and Objectives: Cutaneous wounds are seriously painful and their antibiotic treatments are expensive with adverse effects. Nowadays medicinal herbs are widely used because of lower cost and side effects. Calendula officinalis, Aloe arborescens and Ricinus communis herbs have antimicrobial and healing effects. The aim of the present study was comparing the effect of these three herbal medicines on cutaneous wound healing process in male rat. Materials & Methods: In this experimental study, 32 male adult rats were randomly divided into 4 equal groups of 8, including one control group (wound group and topical use of eucerine in the injured area) and three groups treated with Calendula officinalis, Aloe arborescens and Ricinus communis (topical use of 2cc extract 10%). Wounds with equal thickness were made on the rats&rsquo; back sides and their diameters were measured in the treatment period (21 days) and tissue samples were finally prepared. Data were analyzed by one-way ANOVA and Tukey's post hoc test. Results: Diameter measures of the wounds on the 5th day showed that the average of the wounds&rsquo; diameters in the Calendula officinalis and Ricinus communis treated groups were significantly lower than the control group (p<0.05). At the end of the experiment, the best improvement on cutaneous wound healing &nbsp;belonged to the group treated with Ricinus communis so that there was a significant difference between this group and the control group (p<0.05). Conclusion: Ricinus communis medicinal herb has more improving effect on cutaneous wound healing in rat. Key words: Calendula officinalis, Aloe arborescens, Ricinus communis, Wound healing &nbsp; Funding: This research was funded by University of Zabol and Tehran University of Medical Sciences. Conflict of interest: None declared. Ethical approval: The Ethics Committee of University of Zabol approved the study (UOZ.ECRA.2017.2316905). &nbsp; How to cite this article: Davari SA, Hajinezhad MR, Samadi K, Eftekhari S. The Effect of Calendula, Aloe and Caster on Cutaneous Wounds Healing Process in Mature Male Rat. Univ Med Sci 2018; 17(2): 93-104. [Farsi] &nbsp;