Adriamycin-induced oxidative stress is prevented by mixed hydro-alcoholic extract of Nigella sativa and Curcuma longa in rat kidney

نویسندگان

  • Abolfazl Khajavi Rad Neurogenic Inflammation Research Center, Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Akbar Anaeigoudari Department of Physiology, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran
  • Farimah Beheshti Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Mohammad Naser Shafei Neurocognitive Research Center and department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Mohammad Soukhtanloo Department of Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Noema Mohammadian Roshan Department of Pathology, Qaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
  • Reza Mohebbati Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Sara Hosseinian Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Sareh Karimi Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده مقاله:

Objective: Inflammation and oxidative stress is considered to have a crucial role in induction of nephropathy. Curcuma longa (C. longa) and Nigella sativa (N. sativa) have anti-inflammatory and antioxidant effects. This study was designed to investigate the effect of mixed hydro-alcoholic extract of N.sativa and C. longa on the oxidative stress induced by Adriamycin (ADR) in rat kidney. Material and Method: The animals were divided into 6 groups: control (CO), ADR, Adriamycin+ Vitamin C (ADR+VIT C), C. longa extract+ Adriamycin (C.LE+ADR), N. sativa extract+ Adriamycin (N.SE+ADR) and C. longa extract+ N. sativa extract + Adriamycin (N.S+C.L+ADR). ADR (5mg/kg) was injected intravenously, whereas VITC (100mg/kg) and extract of C. longa (1000mg/kg) and N. sativa (200mg/kg) were administrated orally. Finally, the renal tissue, urine and blood samples were collected and submitted to measure of redox markers, osmolarity and renal index. Results: The renal content of total thiol and superoxide dismutase (SOD) activity significantly decreased and Malondialdehyde (MDA) concentration increased in Adriamycin group compared to control group. The renal content of total thiol and SOD activity significantly enhanced and MDA concentration reduced in treated-mixed extract of C. longa and N. sativa along with ADR group compared to ADR group. The mixed extract did not restore increased renal index percentage induced by ADR. There also was no significant difference in urine and serum osmolarity between the groups. Conclusion: hydro-alcoholic extracts of N.sativa and C.longa led to an improvement in ADR-induced oxidative stress and mixed administration of the extracts enhanced the aforementioned therapeutic effect.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Adriamycin-induced oxidative stress is prevented by mixed hydro-alcoholic extract of Nigella sativa and Curcuma longa in rat kidney.

OBJECTIVE Inflammation and oxidative stress is considered to have a crucial role in induction of nephropathy. Curcuma longa (C. longa) and Nigella sativa (N. sativa) have anti-inflammatory and antioxidant effects. This study was designed to investigate the effect of mixed hydro-alcoholic extract of N.sativa and C. longa on the oxidative stress induced by Adriamycin (ADR) in rat kidney. MATERI...

متن کامل

adriamycin-induced oxidative stress is prevented by mixed hydro-alcoholic extract of nigella sativa and curcuma longa in rat kidney

objective: inflammation and oxidative stress is considered to have a crucial role in induction of nephropathy. curcuma longa (c. longa) and nigella sativa (n. sativa) have anti-inflammatory and antioxidant effects. this study was designed to investigate the effect of mixed hydro-alcoholic extract of n.sativa and c. longa on the oxidative stress induced by adriamycin (adr) in rat kidney. materia...

متن کامل

The protective effects of Curcuma longa extract on oxidative stress markers in the liver induced by Adriamycin in rat

Introduction: The aim of the study was to investigate the effects of Curcuma longa (C. longa) extract on Adriamycin-induced hepatotoxicity in rat. Methods: Animals were divided in six groups: Control (CO), Adriamycin (ADR), Adriamycin with Vitamin C (ADR+VitC), Vitamin C (Vit C), C. longa with Adriamycin (CL+ADR) and without Adriamycin (CL-ADR). Hepatotoxicity was induced by Adriamycin 5mg/kg ...

متن کامل

the protective effects of curcuma longa extract on oxidative stress markers in the liver induced by adriamycin in rat

introduction: the aim of the study was to investigate the effects of curcuma longa (c. longa) extract on adriamycin-induced hepatotoxicity in rat. methods: animals were divided in six groups: control (co), adriamycin (adr), adriamycin with vitamin c (adr+vitc), vitamin c (vit c), c. longa with adriamycin (cl+adr) and without adriamycin (cl-adr). hepatotoxicity was induced by adriamycin 5mg/kg a...

متن کامل

The protective effects of Curcuma longa extract on oxidative stress markers in the liver induced by Adriamycin in rat

Introduction: The aim of the study was to investigate the effects of Curcuma longa (C. longa) extract on Adriamycin-induced hepatotoxicity in rat. Methods: Animals were divided in six groups: Control (CO), Adriamycin (ADR), Adriamycin with Vitamin C (ADR+VitC), Vitamin C (Vit C), C. longa with Adriamycin (CL+ADR) and without Adriamycin (CL-ADR). Hepatotoxicity was induced by Adriamycin 5mg/kg a...

متن کامل

Effects of Grape Seed Proanthocyanidin Extract on Oxidative Stress Induced by Diabetes in Rat Kidney

Background: This study examined the effect of grape seed proanthocyanidin extract (GSPE) on lipid peroxidation content and activity of tissue antioxidant enzymes, including catalase, superoxide dismutase and glutathione peroxidase in diabetic rats. Methods: Thirty male rats were divided into three groups of 10 rats each: control, diabetic and diabetic groups that received 500 mg/kg GSPE for 6 w...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره 6  شماره 1

صفحات  86- 94

تاریخ انتشار 2016-01-01

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023