Beneficial Effects of Nanocurcumin Loaded Chitosan Biofilm on Healing of Full Thickness Excisional Wounds in Diabetic Rats
Objective- In diabetes impaired wound healing and other tissue abnormalities are considered as major concerns. The novel therapeutic options for treatment of wound in diabetic patients are urgently needed. The aim of the present study was to assess beneficial effects of chitosan nanocurcumin biofilm on healing of full thickness excisional wounds in diabetic rats.Design- Experimental StudyAnimals- Forty male diabetic Wistar ratsProcedures- The animals were randomized into four groups of ten animals each. Induction of diabetes was achieved using 60 mg/kg streptozotocin. In group I, 0.1 mL sterile saline 0.9% solution was added to the wounds with no dressing. In group II, the wounds were dressed with chitosan thin-film membranes. In group III, the wounds were treated with curcumin nanoparticles. In group IV, animals with were dressed with chitosan nanocurcumin biofilm. Results- Planimetric, histological and quantitative morphometric studies and determination of hydroxyproline levels showed that there was significant difference between animals in group IV compared to other groups (p = 0.001). Conclusion and clinical relevance- Chitosan nanocurcumin biofilm improved healing of diabetic wound in rats
Evaluation of Application of Chitosan/nano Sodium Selenite Biodegradable Film on Full thickness Excisional Wound Healing in Rats
Objective- This study aimed at evaluation of histopathological findings of application of chitosan- nano selenium biodegradable film on full thickness excisional wound healing in rats. Design- Experimental Study Animals- Seventy-two male Wistar rats Procedures- Animals were randomized into six groups of 12 animals each. Group I: Animals with created wounds and no...متن کامل
Influence of Ferula assa-foetida Loaded Chitosan Nanoparticle Biofilm on Wound Healing in Full-Thickness Wounds Infected with Methicillin Resistant Staphylococcus aureus
Objective- Cutaneous wound healing is an essential physiological process consisting of the collaboration of many cell strains and their products. Initiation of new management for treatment of wound infections caused by multidrug resistant Staphylococcus aureus is required. The aim of the present study was to assess wound healing activity of Ferula assa-foetida...متن کامل
rhEGF-loaded PLGA-Alginate microspheres enhance the healing of full-thickness excisional wounds in diabetised Wistar rats.
Diabetic foot ulcers (DFUs) represent a major clinical challenge in the ageing population. To address this problem, rhEGF-loaded Poly-Lactic-co-Glycolic-Acid (PLGA)-Alginate microspheres (MS) were prepared by a modified w/o/w-double-emulsion/solvent evaporation method. Different formulations were evaluated with the aim of optimising MSs properties by adding NaCl to the surfactant solution and/o...متن کامل
Objective - The objective of the present study was to assess effect of Propolis in combination with chitosan biofilm on excisional wounds. Design- Experimental Study.Animals- Male healthy Wistar rats.Procedures- Sixty-four rats were randomized into four groups of 16 rats each. Group I: Animals with wounds treated with 0.9% saline solution. Group II: Animals with wounds were dr...متن کامل
study the effects of low level laser diode on no production and healing of diabetic and cortisone acetate and normal wounded sd rats
nitric oxide (no) is a small molecule synthesized by most of mammalian cells with diverse biological activities including vasodilatation, host defense and wound healing. impaired wound healing is a common occurrence among diabetics and patients receiving glucocorticoid therapy. on the other hand the application of laser in biomedical area have been increased. thus, the current studies were desi...15 صفحه اول
دوره 15 شماره 1
صفحات 32- 41
تاریخ انتشار 2020-04-01
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