Effects of Crocin on Oxidative Stress Indices in Rat Brain Demylated with Ethidium Bromide

نویسندگان

  • Farbod, Yagoub Assistant Professor, Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  • Fatemi, Rohallah PhD in Physiology, Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  • Fathi-Moghadam, Hadi Professor, Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  • Ghadiri, Ata A. Associate Professor, Department of Immunology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
چکیده مقاله:

Background and purpose: The purpose of this study was to investigate the effects of crocin (Cr) on brain oxidative stress indices in animal model demyelinated with intracerebroventricular ethidium bromide (EB). Materials and methods: In an interventional study, female Wistar rats were randomly divided into 7 groups. Crocin administration was done 1 day after EB injection for 21 days. The values ​​for Glutathione peroxidase (GPx), Superoxide dismutase (SOD), and Malondialdehyde (MDA) were measured before and after receiving Cr and analyzed using Paired t test and ANOVA. Results: The levels of GPx, SOD, and MDA significantly reduced in the group that received Cr100 mg/kg (P<0.05). The effects of crocin were dose-dependent and other doses did not demonstrate significant effects on oxidative stress indices (P< 0.05). Conclusion: The antioxidant effects of Crocin were dose-dependent, and it could be used as a strong antioxidant in management of patients with multiple sclerosis.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effects of Atorvastatin on the Hypertension-Induced Oxidative Stress in the Rat Brain

Background: It is well known that the development of brain oxidative stress is one of the most serious complications of arterial hypertension that evokes brain tissue damage. The aim of this study was to examine the effects of atorvastatin treatment (20 mg/kg/day), as an antioxidant, to prevent the brain tissue oxidative stress in the hypertensive (HTN) rats. Methods: Experiments were performed...

متن کامل

The Effect of NO System on Ethidium Bromide-Induced Oxidative Stress in the Hippocampal Formation of Male Rats

Background Acute and chronic effects of nitric oxide on oxidative stress and neuronal demyelination have been reported in human and animal models.  Objective Oxidative stress is involved in the pathogenesis of demyelinated animals; thus, this study investigated the effects of nitric oxide system and ethidium bromide on oxidative stress in the hippocampal formation.   Methods This experimental...

متن کامل

Neuroprotective effect of nitric oxide donor isosorbide-dinitrate against oxidative stress induced by ethidium bromide in rat brain

This study investigated the effect of systemic administration of isosorbide-dinitrate (ISDN) on oxidative stress and brain monoamines in a toxic model of brain demyelination evoked by intracerebral injection (i.c.i) of ethidium bromide (10 µl of 0.1 %). Rats received saline (control) or ISDN at 5 or 10 mg/kg for 10 days prior to injection of ethidium bromide. Rats were euthanized one day later,...

متن کامل

Neuroprotective effects of crocin on the histopathological alterations following brain ischemia-reperfusion injury in rat

Objective(s): Some histopathological alterations take place in the ischemic regions following brain ischemia. Recent studies have demonstrated some neuroprotective roles of crocin in different models of experimental cerebral ischemia. Here, we investigated the probable neuroprotective effects of crocin on the brain infarction and histopathological changes after transient model of focal cerebral...

متن کامل

Effect of ellagic acid on oxidative stress duo to brain ischemia/hypoperfusion in male rat

Background & Aim: Free radicals are produced in ischemic processes. Nerve damage caused by free radicals may play a role in neurological diseases and antioxidants are protective activity. Ellagic acid is a polyphenol compound with antioxidant properties which is found in fruits like pomegranate, blackberry, and all types of mulberry. This study aimed to evaluate the effect of 14 days of oral ad...

متن کامل

Protective Effects of Crocin on Ischemia-reperfusion Induced Oxidative Stress in Comparison With Vitamin E in Isolated Rat Hearts

BACKGROUND Myocardial Injury caused by ischemia-reperfusion leads to cardiac dysfunction, tissue injury and metabolic changes. The production of reactive oxygen species (ROS) and lipid peroxidation are accompanied by ischemia-reperfusion injury. OBJECTIVES The aim of this study was to assess the cardio protective potential effects of crocin in comparison with vitamin E on antioxidant capacity...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره 29  شماره 172

صفحات  121- 126

تاریخ انتشار 2019-05

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

کلمات کلیدی

کلمات کلیدی برای این مقاله ارائه نشده است

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023