Fetal Vegf Genotype is More Important for Abortion Risk than Mother Genotype

Background VEGF gene has been reported to be related with many diseases and recurrent pregnancy loss in various studies. VEGF polymorphisms are risk factors for pregnancy losses, and generally studies report only women’s genetic analyses. To evaluate the association between VEGF A C405G, C460T, C936T and C2578A polymorphisms and spontaneous abortion, we studied the genotypes of spontaneously aborted fetuses, their mothers and healthy control cases. Methods 23 spontaneously aborted fetal materials, 22 mothers who had these abortions and 86 healthy control cases included to this study. VEGF A C405G, C460T, C936T and C2578A polymorphisms are analysed by Real Time PCR technique after genomic DNA isolation from all samples. Results VEGF A +405GG genotype and +405G allele were higher in fetuses comparing both with mothers and healthy control group. VEGF A +936TT genotype and +936T allele were higher in fetuses comparing with mothers. VEGF A +460C/T polymorphism CT and TT genotypes were higher in fetuses comparing with mothers. Conclusions We ascertained that VEGF A +405C/G, +460C/T, and +936C/T polymorphisms are risk factors for spontaneous abortion in fetal genotypes comparing with their mothers and healthy control cases.