Labdane-Type Diterpene and Two Flavones from Salvia Sharifii Rech. f. and Esfan. and their Biological Activities

Two flavones, ladanein and 6-hydroxy-5,7,4′-trimethoxyflavone and one labdane-typediterpene, ent-13-epi-manoyloxide, were isolated from an ethyl acetate-methanol extract ofthe aerial parts of Salvia sharifii. The compounds were purified using several chromatographicmethods. Structural elucidation of the compounds was performed using their 1H and 13C-NMRdata, EI mass and UV spectral data. The compounds have been subjected to antimicrobial,antioxidant and cytotoxic activity. The diterpene showed higher cytotoxic activity than theflavones while the later compounds were better antioxidants compared with the isolatedditerpene.