Kwang-Won Lee, Sung-Jin Choi, Jae-Hyuk Ahn, Dong-Il Moon, Tae Jung Park, Sang Yup Lee, and Yang-Kyu Choi School of Electrical Engineering and Computer Science, Division of Electrical Engineering, KAIST, Daejeon 305-701, Republic of Korea BioProcess Engineering Research Center, Center for Systems and Synthetic Biotechnology, and Institute for the BioCentury, KAIST, Daejeon 305-701, Republic of K...

در آشکار‌ساز CMS نسبت‌های انشعاب بوزون هیگز مدل استاندارد به جفت‌‌های J/ψ(1S) و cc ترتیب برابر 2-10×1/8 2-10×2/89 اندازه‌گیری شده است. لحاظ نظری یکی از سناریوهای ممکن برای تولید مستقیم این است که آغاز جفت واپاشی نماید سپس مرحله‌ی بعد هر یک کوارک‌های c طور مزون ترکش کنند. بر اساس سناریو مقاله بطریق کوارک‎های با استفاده نظریه اختلال مکانیک کوانتومی رنگ (pQCD) نظر گرفتن حالت‌های قطبش طولی عرضی محا...

Eun-Kyung Kim, Seung-Jae Lee, Jin-Woo Hwang, Chan Gil Kim, Dong Kug Choi, Beong Ou Lim, Hyun Kang, Sang-Ho Moon, Byung-Tae Jeon, and Pyo-Jam Park* 1Department of Biotechnology, Konkuk University, Chungju 380-701, Republic of Korea 2Department of Applied-biochemistry, Konkuk University, Chungju 380-701, Republic of Korea 3Korea Nokyong Research Center, Konkuk University, Chungju 380-701, Republi...

Activating mutations of FMS-like tyrosine kinase 3 (FLT3) are present in approximately 30% of patients with de novo acute myeloid leukemia (AML) and are associated with lower cure rates from standard chemotherapy-based treatment. Targeting the mutation by inhibiting the tyrosine kinase activity of FLT3 is cytotoxic to cell lines and primary AML cells harboring FLT3 mutations. Successful FLT3 in...

Patients with acute myeloid leukemia (AML) harboring internal tandem duplication mutations of the FLT3 receptor (FLT3/ITD mutations) have a poor prognosis compared to patients lacking such mutations. Incorporation of FLT3 inhibitors into existing chemotherapeutic regimens has the potential to improve clinical outcomes in this high-risk group of patients. CEP-701, an indolocarbazole-derived sele...

Endothelins (ETs) are a family of potent vasoactive peptides found in at least three distinct isoforms: ET-1, ET-2, and ET-31}. Two major subtypes of endothelin receptors, termed ETAand ETB, have been identified in various target cells2). It is well known that ETs act on these G protein-coupled receptors and exert multiple pharmacological effects3). As the development of potent and selective en...