Background : Lung cancer is the leading cause of cancer-related mortality over worldwide. Although pathological diagnosis lung carcinoma limited as only small specimen available for diagnosis, availability targeted therapies has created a need precise subtyping non-small cell carcinoma. Several recent studies have demonstrated that use immunohistochemical markers can be helpful in differentiati...

ovine pulmonary adenocarcinoma (opa) was studied in the lungs of 15 naturally-affected sheep (9 with classical and 6 atypical lesions) by transmission electron microscopy. two lung samples from normal sheep were used to develop the ultrastructural criteria. pathologic lesions consisted of focal-multifocal to coalescent nodules or masses in the cranioventral or diaphragmatic lobes. ultrastructur...

introduction: lung cancer is one of the leading causes of cancer related deaths in the world. the incidence of lung cancer is increasing in india and there is a need to understand the natural history of this disease. aim of the study: to study the clinico- pathological- radiological profile of patients diagnosed with lung cancer from january 2013 to may 2015 at a tertiary care teaching hospital...

intraoperative radiation therapy (iort) is a multidisciplinary approach in which residual tumors or tumor beds are directly irradiated during a surgical procedure. to evaluate its efficacy, from 1985, we conducted a prospective study including non-metastatic gastric adenocarcinoma treated by surgery, iort (15 grays) and postoperative external beam radiotherapy (44 grays). up to 1993, 51 cases o...

after curative treatment of hodgkin’s lymphoma, increased risk of certain solid tumors has been reported. to best of our knowledge this is the first report of metachronous pancreatic adenocarcinoma which developed outside the previous radiation field in a patient with relapse hodgkin’s lymphoma. herein we present an 81-year-old female who developed pancreatic adenocarcinoma four years after the...

the tp53 tumor suppressor gene plays important roles in genomic stability. a common polymorphism at codon 72 of tp53 gene has been associated with increased risk for many human cancers. the p53 protein is expressed in colorectal cancer, but the reported prevalence of its expression varies widely. in the present study, the p53 protein expression in different genotypes of its codon 72 , was inves...

BACKGROUND Aberrant DNA methylation is common in lung adenocarcinoma, but its timing in the phases of tumor development is largely unknown. Delineating when abnormal DNA methylation arises may provide insight into the natural history of lung adenocarcinoma and the role that DNA methylation alterations play in tumor formation. METHODOLOGY/PRINCIPAL FINDINGS We used MethyLight, a sensitive real...

Adenocarcinoma no otherwise specified (NOS) and polymorphous low-grade adenocarcinoma (PLGA), are malignant tumors of the salivary glands. Both types have potential for recurrence distant metastases. Rare cases metastases lead to absence standardized systemic therapy gland cancer. This case report aims expand literature regarding parotid adenocarcinoma. We a 54-year-old woman who complained rec...