Genetic epidemiological studies suggest that individual variation in susceptibility to schizophrenia is largely genetic, reflecting alleles of moderate to small effect in multiple genes. Molecular genetic studies have identified several potential regions of linkage and two associated chromosomal abnormalities, and evidence is accumulating in favour of several positional candidate genes. Current...

Refinement of protein structures from a correct topology to atomically detailed resolution has proven remarkably difficult. Jian et al. (in this issue of Structure) illustrate a significant advance in this task by carefully incorporating into the refinement process many body interactions extracted from fragment statistics.

'Assessment is an integral part of the educational process." G ENERAL practice, although the largest medical specialty, Jwas one of the last to enter the universities and medical schools and therefore to become involved with teaching. When it did so in the early 1970S2 general practitioners turned to the edu-cationalists for advice and guidance and as a result adopted a formal model of learning...

Introduction: Our practice-oriented question was ‘how can the community sector work with their local hospitals to smooth the patient’s transition home from hospital’. Our answer was Home At Last, an innovative hospital-community collaboration in the Greater Toronto, Ontario, Canada. Objective: To ensure that when seniors have had a hospital stay or emergency department visit, they are discharge...