Impaired cognitive processing is a hallmark of addiction. In particular, deficits in inhibitory control can propel continued drug use despite adverse consequences. Clinical evidence shows that detoxified alcoholics exhibit poor inhibitory control in the Continuous Performance Task (CPT) and related tests of motor impulsivity. Animal models may provide important insight into the neural mechanism...

in many jurisdictions, psychiatric problems are intended for commutation. therefore, a forensic psychiatrist has an important role in detection of malingering. while several studies evaluate diagnostic tests, it is less known what symptoms are more likely to be imitated by malingerers.in a prospective study 45 malingerers, who were diagnosed according to interviews by two forensic psychiatrists...

BACKGROUND Recent studies suggest that behavioral variant frontotemporal dementia (bv-FTD) patients differ in their prognosis with fast-progressing and very slow-progressing cases. We investigated executive and behavioral profiles of progressive and nonprogressive bv-FTD patients to establish diagnostic markers discriminating the two groups. METHODS A range of neuropsychological and behaviora...

aim and background: there are various methods for treatment of depression. this study was aimed to examine and compare the efficacy of three therapeutic techniques namely group cognitive-behavioral psychotherapy, drug therapy with fluoxetin and drug- therapy with the herbal medicine named hypiran in treatment of depression in women. method and materials: in an experimental study, a total number...

Rats with myocardial infarction provide a clinically relevant model for hemodynamic and survival studies. Moreover, behavioral changes in this model, i.e. increased anxiety and reduced interest in environment and social interactions, mimic aspects of the reduced quality of life of patients. In the present study, we investigated whether pharmacological treatment that is known to improve hemodyna...

As more investigators with widely varying backgrounds enter the field of mouse behavioral genetics, there is a growing need to standardize some of the more popular tests because differences between laboratories in the details of behavioral testing and the pretesting environment can contribute to failures to replicate results of genetic experiments. It is argued here that we have sufficient know...

Defining anxiety- and depressive-like states in mice (emotionality) is best characterized by the use of complementary tests, leading sometimes to puzzling discrepancies and lack of correlation between similar paradigms. To address this issue, we hypothesized that integrating measures along the same behavioral dimensions in different tests would reduce the intrinsic variability of single tests a...

Behavioral tests of animals in a controlled experimental setting provide a valuable tool to advance understanding of genotype-phenotype relations, and to study the effects of genetic and environmental manipulations. To optimally benefit from the increasing numbers of genetically engineered mice, reliable high-throughput methods for comprehensive behavioral phenotyping of mice lines have become ...