background and objectives: in the original in vitro method for evaluation of iron bioavailability using caco-2 cell model, ferritin formation by cells is considered as a functional indicator of both absorption and utilization of iron. however, as iron is measured in the tested material and then ferritin concentration is measured in caco-2 cell lysate, it is almost impossible to have a concrete ...

Facility layout is one of the most important Operations Management problems due to its direct impact on the financial performance of both private and public firms. Facility layout problem (FLP) with stochastic parameters, unequal area facilities, and grid system modeling is named GSUA-STFLP. This problem has not been worked in the literature so that to solve GSUA-STFLP is our main contribution....

A number of di€ erent performance measures have been used in the design and analysis of material handling systems. These performance measures have measured either: (1) the entire manufacturing system (e.g. job throughput), or (2) the material handling system independently (e.g. vehicle travel distance). The following is a review of performance, reliability, and performabilitymeasures used in th...

o bjectives: the aim of this study was to assess the cytotoxic effects and osteogenic activity of recombinant human bone morphogenetic protein (rhbmp2) and nano-hydroxyapatite (n- ha) adjacent to mg-63 cell line. mat erials and methods: to assess cytotoxicity, the 4,5-dimethyl thiazolyl-2,5-diphenyl tetrazolium bromide (mtt) assay was used. alkaline phosphatase (alp) activity and oste- ogenic a...

We will present a progress report on our effort to develop a science-based design methodology for warehousing systems. In particular, we will discuss the hierarchical structure of our design procedure. This includes the decisions and parameters used in the master model, the various sub-models, and the decision and data interaction between the various levels in the hierarchy. We will present sev...

Simulation is used to verify the feasibility of the design of manufacturing cells. The cell design, which combines new and existing machines in a component manufacture, is presented, showing the difficulties that can result with such a system. Simply changing the layout (arranging machines into cells) could provide some benefits, but these benefits were offset by a high level of required invest...

The majority of the issued facilities layout problems (FLPs) minimize the material handling cost and ignore other factors, such as area utilization, department shape and site shape size. These factors, however, might influence greatly the objective function and should give consideration. The research range of this paper is focus on the unequal areas department facilities layout problem, and imp...

The paper presents a model of designing of machine layout in flexible manufacturing system (FMS). Evolutionary computation, particularly genetic algorithms (GAs) proved to be successful in search of optimal solution for this type of problems. To achieve high productivity in a flexible manufacturing system (FMS), an efficient layout arrangement and material flow path design are important due to ...