Che-1 is a RNA polymerase II binding protein involved in the transcriptional regulation of E2F target genes and in cell proliferation. Recently, it has been shown that Che-1 accumulates in cells responding to genotoxic agents such as Doxorubicin and ionizing radiation. The DNA damageactivated checkpoint kinases ATM and Chk2 interact with and phosphorylate Che-1, enhancing its accumulation and s...

The aim of this study was to determine the effects of a bacterial inoculant and chemical additives on nutrient composition, in vitro degradation, total loss, aerobic stability, microbiological quality, and fermentative profile of sugarcane silage. Treatments were distributed to forty-eight mini-silos in a 2 × 4 factorial arrangement: two levels of microbial inoculant (INO, 0 or 4 g/t of fresh s...

" Dicono che c'` e un tempo per seminare e unopì u lungo per aspettare Io dico che c'era un tempo sognato che bisognava sognare "

OBJECTIVE The objective of the study was to document the effectiveness of a Cholinesterase Inhibitor (ChE-I) Review Committee in a long-term care (LTC) institution in Montreal, Canada. DESIGN Retrospective cohort study. SETTING Maimonides Geriatric Centre (MGC), a 387-bed LTC facility in Montreal, Canada, in which 352 patients have dementia. PARTICIPANTS Fifty-two patients on ChE-I who we...

Objective(s): New generation of allergy vaccines is capable of promoting the development of protective IgG and blocking the functionality of allergen-specific IgE. We incorporated universal and powerful T-cell epitopes from tetanus and diphtheria toxoids (TD epitope) into recombinant Che a 2, the well-known allergic profilin of Chenopodium album, to determine its immun...

To elucidate the mechanism of sensory cilium formation, we analyzed mutants in the Caenorhabditis elegans che-2 gene. These mutants have extremely short cilia with an abnormal posterior projection, and show defects in behaviors that are mediated by ciliated sensory neurons. The che-2 gene encodes a new member of the WD40 protein family, suggesting that it acts in protein-protein interaction. An...

Neurotrophin receptor-interacting MAGE homolog (NRAGE) has been recently identified as a cell-death inducer, involved in molecular events driving cells through apoptotic networks during neuronal development. Recently, we have focused on the functional role of Che-1, also known as apoptosis-antagonizing transcription factor (AATF), a protein involved in cell cycle control and gene transcription....

Lo scopo di questo articolo è l’analisi delle proprietà di una costruzione ricorrente in spagnolo, come in numerose altre lingue geneticamente diverse, dove un argomento dativo non nucleare viene aggiunto ad una costruzione anticausativa e può essere interpretato come una causa accidentale o non intenzionale dell’evento, Prima si stabilisce che l’aggiunta di un argomento dativo ad una tipica st...

BACKGROUND In the absence of functional social security mechanisms for elderly people in Nigeria, elderly households are solely responsible for geriatric healthcare costs, which can lead to catastrophic health expenditures (CHE) - particularly among the poor. This study investigates the key determinants of CHE among poorly insured elderly households in Nigeria. We also offer some policy options...