COX-2 inhibitory activities of some 1,4-dihydropyridine and 5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives were modeled by quantitative structure–activity relationship (QSAR) using stepwise-multiple linear regression (SW-MLR) method. The built model was robust and predictive with correlation coefficient (R2) of 0.972 and 0.531 for training and test groups, respectively. The quality of the mod...

the waiting time between children births are called tempo. this phenomenon plays a crucial role in the child and mother health. the purpose of the present study is determination of factors which influence this variable of interest. a significance level of 5% and power of 80% considered to calculate the required sample size for this cross sectional study. the sample size of 124 women determined ...

objective: tempo is the average waiting time to next birth for a woman. role of fertility as the most important phenomenon determining population fluctuations due to the studies of it compared with other demographic phenomena be important and review the multifarious socioeconomic factors of it share  a large effective population studies. general purpose of this study is fitting the cox model to...

Abstract We consider high‐dimensional inference for potentially misspecified Cox proportional hazard models based on low‐dimensional results by Lin and Wei (1989). A desparsified Lasso estimator is proposed the log partial likelihood function shown to converge a pseudo‐true parameter vector. Interestingly, sparsity of true can be inferred from that above limiting parameter. Moreover, each compo...

Cyclooxygenases-1 and -2 (Cox-1 and Cox-2) are two distinct isoforms that catalyze the conversion of arachidonic acid to prostaglandins. The role of Cox-2 in a variety of cancers is well recognized, but the contribution of Cox-1 remains much less explored. We have previously shown that human epithelial ovarian tumors have increased levels of Cox-1, but not Cox-2. We also observed that Cox-1 is ...