BACKGROUND Previous studies found that patients with depressive disorders frequently have lifetime manic symptoms or even an unrecognized bipolar disorder and that these patients have more severe illness. In this study we investigated whether the presence of significant manic symptoms among patients presenting with depressive and/or anxiety disorders is associated with more severe illness, more...

OBJECTIVES To assess the available evidence on the prevalence, aetiology, treatment, and prevention of anxiety and depressive disorders in Pakistan. DESIGN Systematic review of published literature. STUDIES REVIEWED 20 studies, of which 17 gave prevalence estimates and 11 discussed risk factors. MAIN OUTCOME MEASURES Prevalence of anxiety and depressive disorders, risk factors, effects of...

BACKGROUND Inconsistent findings have been reported on the role of comorbid alcohol use disorders as risk factors for a persistent course of depressive and anxiety disorders. AIMS To determine whether the course of depressive and/or anxiety disorders is conditional on the type (abuse or dependence) or severity of comorbid alcohol use disorders. METHOD In a large sample of participants with ...

OBJECTIVE To evaluate the presence of Major Depressive Disorder (MDD) and Dysthymic Disorder (DD) in a sample of Italian children with Attention Deficit Hyperactivity Disorder (ADHD) and to explore specific features of comorbid depressive disorders in ADHD. METHODS Three hundred and sixty-six consecutive, drug-naïve Caucasian Italian outpatients with ADHD were recruited and comorbid disorders...

late life depression is both underdiagnosed and undertreated. the impact of medical conditions may mask depressive symptoms. untreated depressive disorder in older people impair their quality of life and leads to decreased ability for self care and diminish in social interaction and increase in health care use. this article provides an update and current evidence in relation to old age depressi...

genetic studies were carried out on a total of 196 psychiatric patients, hospitalized in sorkhe hesar, roozbeh, cherazi and chaharom aban hospitals. out of all the patients studied, 74 were schizophrenic, 30 manic-depressive, 47 depressive (neurotic), 12, hysteric, 9 epileptic and the remainder had different psychiatric diseases and conditions such as: anxiety and phobia, scrupulousness mental ...

The current study was a prospective exploration of the specificity of early childhood adversities as predictors of anxiety and depressive disorders in adolescents. Participants were 816 adolescents (414 males, 402 females) with diagnostic information collected at age 15; information on early adversities had been collected from the mothers during pregnancy, at birth, age 6 months, and age 5 year...

OBJECTIVE Several cross-sectional studies have related depressive and anxiety disorders to shorter leukocyte telomere length (LTL) as an indicator of cellular aging. However, these studies have left many unresolved questions about underlying causality and ordering of associations. The objective of the present large, longitudinal study was to examine the relationship between depressive and anxie...