OF THE DISSERTATION The Use of Arti cial Intelligence to Improve the Numerical Optimization of Complex Engineering Designs by Mark A. Schwabacher Dissertation Directors: Thomas Ellman and Andrew Gelsey Gradient-based numerical optimization of complex engineering designs promises to produce better designs rapidly. However, such methods generally assume that the objective function and constraint ...

The introduction of ultralow volume (ULV) application of the organophosphate pesticide Fenitrothion in grain terminals presents a risk to workers of skin contact with concentrate. Blood testing, by the Ellman method, of a group of five grain terminal workers working on grain treatment showed a lowering of mean red blood cell cholinesterase (RBC ChE) activity to 23 units/gm Hb (normal value 28-4...

An inhibitive assay of insecticides using Acetylcholinesterase (AChE) from the local fish Clarias batrachus is reported. AChE was assayed according to the modified method of Ellman. Screening of insecticide and heavy metals showed that carbofuran and carbaryl strongly inhibited C. batrachus AChE. The inhibition concentration (IC) IC50 values (and the 95% confidence interval) for both carbofuran...

Acetylcholinesterase enzyme (AChE) is the that catalyzes hydrolysis of neurotransmitter acetylcholine to choline. Inhibitors this (AChE-i) are used treat Alzheimer's, a neurodegenerative disease. Due side effects drugs used, there has been an increased interest in investigating inhibitory potentials natural products which presumed have fewer effects. For purpose, highland honey, chestnut royal ...

"Rheumatoid disease" in its acute or chronic form with systemic or local manifestations may simulate many diseases in general medicine. Local manifestations may resemble many specific arthritides and bony and muscular lesions with secondary joint involvement (Ellman, 1947; Ellman and Ball, 1948), and two cases of a chondro-osseous dystrophy, which had been regarded as an arthritic manifestation...

Alzheimer hastalığı (AH), zamanla beyin hücrelerinin ölümüne bağlı olarak bilişsel işlevlerde azalma, hafıza kaybı ve bunama ile ilişkilendirilmiştir. hastalığının tedavisinde sınırlayıcı uygulamaların mevcut oluşu, hastalığın sağlık harcamalarında kanser kalp hastalıklardan sonra dünyada üçüncü sırada oluşu araştırmacıları AH üzerinde erken evrede tanıma yeni tedavi yöntemlerine yönlendirmekte...

This study was undertaken to evaluate anticholinesterase activity of some benzimidazole derivatives due to their biological importance. Previously synthesized 14 benzimidazole compounds were used in biological studies. Inhibitory activities of related compounds on Acetylcholine esterase (AChE, E.C.3.1.1.7 from Electric Eel) enzyme have been determined by a modified Ellman’s colorimetric method....

Objective(s): Methamphetamine (METH) is a powerful stimulant drug that directly affects the brain and induces neurological deficits. B12 is a water-soluble vitamin (vit) that is reported to attenuate neuronal degeneration. The goal of the present study is to investigate the effect of vitamin B12 on METH’s neurodegenerative changes.Materials and Methods: Two groups of 6 animals received METH (10...