PCSK9 is a circulating protein, synthesized predominantly in the liver, involved in the regulation of the plasma low-density lipoprotein (LDL)–cholesterol concentration and associated with susceptibility to coronary heart disease (CHD). Proprotein convertase subtilisin/kexin type 9 (PCSK9) shortens the half-life of the LDL-receptor (LDLR), a process independent of its catalytic activity. Human ...

BACKGROUND The potential physiological significance of the nanophase transition of neutral lipids in the core of low density lipoprotein (LDL) particles is dependent on whether the rate is fast enough to integrate small (+/-2 degrees C) temperature changes in the blood circulation. METHODOLOGY/PRINCIPAL FINDINGS Using sub-second, time-resolved small-angle X-ray scattering technology with sync...

Oxidized low-density lipoprotein (OxLDL) and autoantibodies to OxLDL (aOxLDL) are implicated in the development of atherosclerosis. The objective of this study was to determine the importance of these factors in hypertension, a major risk factor for atherosclerosis. Samples were obtained from 111 men with established hypertension (diastolic pressure >95 mmHg) from the Swedish component of an on...

The hypothesis that oxidized LDL (ox-LDL) is necessary, if not obligatory, in the development of atherosclerotic lesions was formulated .20 years ago with the seminal observation that uptake of native LDL by macrophages did not result in foam cell formation. In contrast, uptake of ox-LDL via scavenger receptors resulted in the unregulated accumulation of lipid.1 Since then, multiple studies in ...

It has been reported that green tea consumption reduces the risk of coronary artery disease and cardiac events. Catechin is a major constituent of Japanese green tea and an antioxidant. Lipids and oxidization of low-density lipoprotein cholesterol (LDL-C) play important roles in atherosclerosis. Therefore, we evaluated the effect of catechin intake on the lipid profile and plasma oxidized LDL. ...

Atherogenic modification of low-density lipoprotein (LDL) plays a crucial role in the pathogenesis of atherosclerosis, as modified LDL, but not native LDL, induces pronounced accumulation of cholesterol and lipids in the arterial wall. It is likely that LDL particles undergo multiple modifications in human plasma: desialylation, changes in size and density, acquisition of negative electric char...

We have used the ionisation equilibrium equation to derive the electron density in in-terstellar clouds in the direction to 13 stars. A linear relation was found, that allows the determination of the electron density from the Mg I and Mg II column densities in interstel-lar medium. The comparison of normalised equivalent width of 12 DIBs with the electron density shows that the DIBs equivalent ...

Independent component analysis (ICA), formulated as a density estimation problem, is extended to a mixture density model. A number of ICA blocks, associated to implicit equivalent classes, are updated in turn on the basis of the estimated density they represent. The approach is equivalent to the EM algorithm and allows an easy non linear extension of all the current ICA algorithms. We also show...

Plasma proteins of the rat have been labelled by the in vivo injection of the dye T-1824. From a study of the rate of disappearance of T-1824 from the circulating blood, and the total T-1824 content of the perfused kidney the rate of protein reabsorption from the glomerular fluid by the cells of the renal tubule has been calculated. It is concluded that protein reabsorption by the cells lining ...