The nearest-neighbor level-spacing distributions are a fundamental quantity of disordered systems and classified into different universality classes. They the Wigner-Dyson Poisson functions for extended localized states in Hermitian systems, respectively. follow Ginibre non-Hermitian whose eigenvalues complex away from exceptional points (EPs). However, near EPs still unknown, corresponding ran...

We present a method to compute the holonomic extension of a D-module from a Zariski open set in affine space to the whole space. A particular application is the localization of coherent D-modules which are holonomic on the complement of an affine variety. Throughout this article let R = K[x1, . . . , xn] be the ring of polynomials in n variables over the field K of characteristic zero and D = R...

Constructed wetlands (CWs) are engineered water treatment systems designed to remove various types of contaminants. A large number of processes simultaneously contribute to water quality improvement in CWs. During the last decade, there has been a wide interest in the understanding of complex “constructed wetland” systems, including the development of numerical process-based models describing t...

Background and aims: Anal sphincter weakness and rectal sensory disturbances contribute to faecal incontinence (FI). Our aims were to investigate the relationship between symptoms, risk factors, and disordered anorectal and pelvic floor functions in FI. Methods: In 52 women with ‘‘idiopathic’’ FI and 21 age matched asymptomatic women, we assessed symptoms by standardised questionnaire, anal pre...

Rational approaches have been extensively used to investigate the role of active site residues in cytochrome P450 (CYP) functions. However, recent studies using random mutagenesis suggest an important role for non-active site residues in CYP functions. Meta-analysis of the random mutants showed that 75% of the functionally important non-active site residues are present in 20% of the entire prot...