In this work, quantitative structure-retention relationship (QSRR) approaches were applied for modeling and prediction of the retention index of 282 amino acids (AAs) and carboxylic acids (CAs). Descriptors that were used to encode structural features of molecules in a data set were calculated by using the Dragon software. The genetic algorithm (GA) and stepwise multiple linear regression (MLR)...

Dichloroacetate (DCA) is a simple and small anticancer drug that arouses the activity of the enzyme pyruvate dehydrogenase (PDH) through inhibition of the enzyme pyruvate dehydrogenase kinases (PDK1-4). DCA can selectively promote mitochondria-regulated apoptosis, depolarizing the hyperpolarized inner mitochondrial membrane potential to normal levels, inhibit tumor growth and reduce proliferati...

In this contribution, genetic programming is combined with continuum regression to produce two novel non-linear continuum regression algorithms. The first is a ‘sequential’ algorithm while the second, adopts a ‘team-based’ strategy. Having discussed continuum regression, the modifications required to extend the algorithm for non-linear modelling are outlined. The results of applying the derived...

Research has yielded approaches for predicting future changes and defects in software artifacts, based on historical information, helping developers in effectively allocating their (limited) resources. Developers are unlikely able to focus on all predicted software artifacts, hence the ordering of predictions is important for choosing the right artifacts to concentrate on. We propose using a Ge...

in this study, a bi-objective model for integrated planning of production-distribution in a multi-level supply chain network with multiple product types and multi time periods is presented. the supply chain network including manufacturers, distribution centers, retailers and final customers is proposed. the proposed model minimizes the total supply chain costs and transforming time of products ...

Abstract Multimedia music information teaching is a fundamental approach to the balanced development of education in China. This paper uses comprehensive evaluation index and multiple linear regression analysis make statistics network multimedia survey data. Then it discusses music’s influencing factors from subjective objective aspects. The results show positive correlation with final training...

Photoacoustic spectroscopy technology is an important method to detect the concentration of trace gases, so it great significance improve detection accuracy photoacoustic system (PAS). In this paper, a multiple linear regression algorithm was proposed correct PAS based on high-precision cavity ring-down measurement system. The results showed that correlation coefficient R2 between corrected val...