lowering the glucose level in diabetic patients reduces the risk of many consequences which are usually reported in these patients. non-insulin dependent (type ii) diabetes which cannot be controlled with sulfonylureas alone can be controlled with a combination of sulfonylurea and insulin. in an open randomized trial 58 patients were divided into three groups. the first group received only insu...

Chronic progressive metabolic problem and chronic hyperglycemia caused by a dysregulation of protein, lipid, carbohydrate metabolism are two symptoms diabetes mellitus, complicated condition. Verapamil belongs to group calcium channel blockers that not dihydropyridines. It works preventing from entering beta cells' cytoplasm, the second phase insulin release driven glucose, as well sulfonylurea...

OBJECTIVE To assess the effect of overnight insulin pump suspension in an automated predictive low glucose suspend system on morning blood glucose and ketone levels in an attempt to determine whether routine measurement of ketone levels is useful when a closed-loop system that suspends insulin delivery overnight is being used. RESEARCH DESIGN AND METHODS Data from an in-home randomized trial ...

The stability of a discrete-time Glucose Insulin interaction system is considered in this paper. The system is modeled with difference equations. Local stability conditions about the equilibrium points are obtained. The phase portraits are obtained for different sets of parameter values. Also bifurcation diagrams are provided for selected range of parameter. Numerical simulations are carried ou...

BACKGROUND In order to stave off deleterious complications of the disease, the ultimate task for people with diabetes is to maintain their blood glucose in euglycemic range. Despite technological advancements, conventional open-loop therapy often results in prolonged hyperglycemia and episodic hypoglycemia, in addition to necessitating carbohydrate counting, frequent glucose monitoring, and dru...

Introduction: Diabetes is one of the most common endocrine diseases. With regard to the importance of blood glucose regulation in prevention of diabetic complications, glycemic and insulinemic response determination of foods containing carbohydrates is greatly important. The purpose of the present study, therefore, was to determine the effect of low glycemic index foods taken at dinner on fasti...

Analyses of the control of glucose metabolism by insulin have been hampered by changes in bloog glucose concentration induced by insulin administration with resultant activation of hypoglycemic counterregulatory mechanisms. To eliminate such mechanisms, we have employed the glucose clamp technique which allows maintenance of fasting blood glucose concentration during and after the administratio...

The pancreas is an elongated organ that extends across the abdomen, below the stomach. In addition, it secretes certain enzymes that aid in food digestion. The pancreas also manufactures hormones responsible for regulating blood glucose levels. In the present paper, we propose a mathematical model to study the homeostasis of glucose and insulin in healthy human, and a simulation of this model, ...