Leptospirosis is a worldwide zoonosis caused by pathogenic Leptospira. The whole-genome sequence of L. interrogans serovar Copenhageni together with bioinformatics tools represent a great opportunity to search for novel antigen candidates that could be used as subunit vaccine against leptospirosis. We focused on six genes encoding for conserved hypothetical proteins predicted to be exported to ...

Intracellular delivery of functional macromolecules using peptide transduction domains (PTDs) is an exciting technology with both experimental and therapeutic applications. Recent data indicate that PTD-mediated transduction occurs via fluid-phase macropinocytosis involving an intracellular pH drop to approximately 5. Nitrilotriacetic acid (NTA)-coordinated metals avidly bind hexahistidine-tagg...

Observers of contemporary politics know that Islamic extremism presents ‘the West’ with a serious challenge of national and international security consequent to terrorist events of recent time. In addition to constabulary and military responses, there remains the more fundamental question about how to understand Islamist ideology and how counternarratives might be framed in the interest of law ...

A teacher's problem, as diagnosed by the author of this book, appears to be that he is incurably middle-class in his ideas, economically dependent on continuing to be so, and yet socially barely on the fringe of the bourgeoisie. He suffers therefore, it is contended, all the privations?social, sexual and psychological?of his religious and moral ideology without the corresponding middle-class co...

Interview with Randall Packard, William H. Welch Professor of the History of Medicine at The Johns Hopkins University and co-editor of the Bulletin of the History of Medicine. Speaking about his academic career, his activities as an editor, and his main works, Professor Packard addresses the topics of health and disease in the history of Africa; the relation between disease eradication programs...

all along history, the art and society always have interplayed. literary works especially novel are rooted in contemporary society and tell us about social, political, cultural and historical issues of a society. a realistic novel may reflect realities of its time like a mirror. the sociology of literature is aimed to explain the links between society and literature and clarifying the quality o...

the widely shocking attacks on the world trade center and the pentagon on september 11 was interpreted differently by various institutions worldwide, ranging from america's legitimate motive to begin a 'war on terror' to defend her 'very freedom', to a pretext for bush administration to pursue g. h. w. bush's temptation for 'a new world order'. various institutions, therefore, made use of their...