BACKGROUND Lower airway obstruction has evolved to denote pathologies associated with diseases of the lung, whereas, conditions proximal to the lung embody upper airway obstruction. This approach has disconnected diseases of the larynx and trachea from the lung, and removed the 'middle airway' from the interest and involvement of respiratory physicians and scientists. However, recent studies ha...

I t is evident that anyone required to perform at a high level in sport or other physically demanding occupation has a limited number of years before demands made on the body begin to take their toll, sometimes accompanied by difficulties of a psychological nature. Although there may be a good deal of informal support from family, friends, and perhaps even other athletes who have retired, in so...

Page 1 Overview of cAMP Signaling The transduction of extracellular signals to intracellular responses is one of the most important and complicated aspects of cellular life. The cyclic adenosine monophosphate (cAMP) signaling pathway is involved in numerous processes and is widely regarded as the “classical” second messenger signaling pathway. cAMP is synthesized from adenosine triphosphate (AT...

Depth psychology finds empirical validation today in a variety of observations that suggest the presence of causally effective mental processes outside conscious experience. I submit that this is due to misinterpretation of the observations: the subset of consciousness called "meta-consciousness" in the literature is often mistaken for consciousness proper, thereby artificially creating space f...

Signaling through the cyclic adenosine monophosphate-dependent protein kinase [protein kinase A (PKA)] is an important and widely studied area of signal transduction research. This signaling pathway is commonly investigated through the use of the pharmacological PKA inhibitors H89 and KT 5720. Both of these compounds are thought to block PKA actions through competitive inhibition of the adenosi...