interleukin (il)-35 is a newly discovered suppressive cytokine and has been shown to alleviate  inflammatory  and  autoimmune  diseases.  the  purpose  of  this  study  was  to investigate immunomodulatory capacity of il-35 in patients with allergic asthma.il-35 mrna expression levels in peripheral blood mononuclear cells (pbmcs) were detected  by  quantitative  real-time  pcr  (qpcr).  the  fr...

Objective(s): Systemic lupus erythematosus (SLE) is a multi-factorial autoimmune disease which may be characterized by T lymphocytes dysfunctions. Th17 cells have been identified as new effector cells, which play an important role in the pathogenesis. In recent years, immunomodulatory effect of vitamin D3 has been noticed. In the present experiment, the effect of vitamin D3 on the expression of...

Polystyrene nanoplastics (NP) are often found in aquatic environments. The accumulation of biota such as fish, shrimp, squid, shellfish, etc. can reduce the health humans who consume them. purpose this study was to observe red seaweed’s potential a source antioxidants improving immune system and reproductive rats (Rattus novergicus) exposed nanoplastics. Twenty-five norvegicus) were divided int...

Interferon (IFN)-γ is a potent proinflammatory molecule. However, few studies have investigated the expression levels of IFN-γ during pelvic organ prolapse (POP). In the present study, the expression levels and tissue localization of IFN-γ and its pathway-associated genes were detected in the vaginal walls of premenopausal females with POP and asymptomatic controls using quantitative polymerase...

objective(s): systemic lupus erythematosus (sle) is a multi-factorial autoimmune disease which may be characterized by t lymphocytes dysfunctions. th17 cells have been identified as new effector cells, which play an important role in the pathogenesis. in recent years, immunomodulatory effect of vitamin d3 has been noticed. in the present experiment, the effect of vitamin d3 on the expression of...

Background: There are many therapeutic methods for allergic conditions. CpG oli-gonucleotides play a critical role in immunity via the augmentation of Th1 and suppres-sion of Th2 responses. Objective: In the present study we aimed to estimate the effec-tiveness of intranasal administration of CpG ODN plus Chenopodium album allergen in allergic asthma compared with the administration of allergen...

there are limited clinical investigations identifying the percentage of t helper 1 (th1) and t regulatory (treg) cells in stable as well as rejected kidney allografts, a concept which needs to be more studied. the aim of our study was to compare the percentage of cd4+ ifn-γ+ cells, the number of ifn-γ secreting cells and the amount of foxp3 expression in patients with or without stable graft fu...

background: there are many therapeutic methods for allergic conditions. cpg oli-gonucleotides play a critical role in immunity via the augmentation of th1 and suppres-sion of th2 responses. objective: in the present study we aimed to estimate the effec-tiveness of intranasal administration of cpg odn plus chenopodium album allergen in allergic asthma compared with the administration of allergen...

OBJECTIVES Compare the effect of different doses of red maca on gamma interferon (IFN-γ) levels in ovariectomized rats (OVX). MATERIALS AND METHODS Adult female rats were randomly divided into the following six groups: Group 1: pseudo-ovariectomized rats (PO); Group 2: OVX rats; Group 3: OVX rats treated with 4 ug/kg estradiol; and Group 4, 5 and 6: OVX rats treated with red maca extracts wit...