Eugenol and carvacrol from clove and oregano, respectively, are agonists of the warmth-sensitive transient receptor potential channel TRPV3 and the irritant-sensitive transient receptor potential ankyrin (TRPA)-1. Eugenol and carvacrol induce oral irritation that rapidly desensitizes, accompanied by brief enhancement of innocuous warmth and heat pain in humans. We presently investigated if euge...

Zataria multiflora is one of the valuable medicinal plants belonging to the Lamiaceae family. The aromatic aerial parts of this species are traditionally used by endemic folks to flavor some native foods, also for numerous therapeutic functions. In the present study, different plant organs (leaf, flower, stalk and whole aerial organ) were collected from Fanuj region of Sistan & Balouchestan pro...

Hypertension-induced left ventricular hypertrophy is the most important risk factor for heart failure. This study aimed at investigating the effects of monoterpenoid phenol, carvacrol, on myocardial hypertrophy using both in-vivo and in-vitro models. Male Wistar rats were divided into the control (Ctl), un-treated hypertrophy (H), and carvacrol-treated hypertrophy gro...

The essential oils from oregano (Origanum syriacum L.) and laurel (Laurus nobilis L.), their main components, namely, carvacrol, 1,8-cineole α-pinene, were tested to determine inhibitory effects on the seed germinations of three different weeds [redroot amaranth (Amaranthus retroflexus wild licorice (Glycyrrhiza glabra curled dock (Rumex crispus cutleaf ground-cherry (Physalis angulata L.)] cro...

Introduction: Greatly increased use of antifungal therapies has resulted in the development of multidrug resistant. The phenolic compound carvacrol have been reported to have anti-Candida activity. This work is an attempt to examine effect of carvacrol on ergosterol synthesis against multidrug resistant Candida albicans. Methods: This cross-sectional study has been conducted on 30 immune-compr...

Pomegranate juice (PJ) and its products are directly used in foods due to their pleasant taste and palatability as well as preservative effects. In spite of useful effects of essential oils such as zataria multiflora Boiss essential oil (ZEO) on prolonging shelf-life of foods, their application is restricted due to their vigorous taste and aroma. In the present study, physicochemical characteri...

A gas liquid chromatographic analysis of the essential oils from four new Greek Oregano clones revealed that carvacrol was the predominant constituent in all clones, representing extremely high percentages of the oils (from 79.5% in a clone named Athos to 93% in a clone named Olympus). The thymol content ranged from 0.04 to 0.55 percent among the tested clones. Phenols (carvacrol and thymol) an...

OBJECTIVE The increasing prevalence of antibiotic-resistant bacterial infections led to identify alternative strategies for a novel therapeutic approach. In this study, we synthesized ten carvacrol codrugs - obtained linking the carvacrol hydroxyl group to the carboxyl moiety of sulphur-containing amino acids via an ester bond - to develop novel compounds with improved antimicrobial and antibio...

Background and Objective: A huge amount of investigational evidence support a role for oxidative stress as an intermediary of nerve cell dysfunction in Parkinson’s disease (PD). Polyphenols such as carvacrol have been indicated to prevent neuronal deterioration caused by increased oxidative load, thus, this study evaluated whether carvacrol administration would attenuate behavioral abnormalitie...