We welcome the commentary of Ziegler et al. (1) and are delighted to have the opportunity to clarify certain details of the study that were included in our first submission but had to be omitted because of article length restrictions. We don’t agree with the statement that because the number of subjects included with confirmed diabetic sensorimotor polyneuropathy (DSPN) was presumably low, our ...

Three dimensional quantitative structure activity relationship between diazabicyclo[4.2.0]octanes and nicotinic acetylcholine receptor (halpha4beta2 and halpha3beta4) agonists was studied using comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA). From 11 CoMFA and CoMSIA models, CoMSIA with steric and electrostatic fields gave the best pre...

Abstract Ombrogenous peat bogs at lower altitudes of the Bohemian Massif occur close to their natural climatic limits in Northern Hemisphere. They have been significantly affected by extraction and severe acidification. Recently, climate change effects, such as decreased snow cover summer heat waves, resulted frequent seasonal desiccation these habitats, indicating ongoing transition into a dif...

A 24-year-old woman presented with a history of swelling and heaviness in her right upper extremity following swimming or any prolonged physical activity involving overhead arm abduction. She noted occasional numbness and paresthesia. Electromyography (EMG) and nerve conduction velocity (NCV) results were normal. Venogram demonstrated high-grade narrowing of the subclavian vein at the thoracic ...

Abbreviations: GSTs: Glutathione S-Transferases; DM: Myotonic Dystrophy; PROMM: Proximal Myotonic Myopathy; ROS: Reactive Oxygen Species; Ile: Isoleucine; Val: Valine; EMG: Electromyographia; NCV: Nerve Conduction Velocity; OD: Optical Density; SNP: Single Nucleotide Polymorphisms; LWD: Learning and Writing Disability; SLD: Speech and Languages Disability; SCK: Serum Creatine Kinase; CK-MM: Cre...