normal 0 false false false en-us x-none ar-sa background: botulinum toxin a (bta) is a promising therapeutic option in the treatment of allergic rhinitis (ar). although recent studies have introduced bta septal injection as an alternative method, the conventional localization for the injection of bta in patients with ar is still the nasal turbinates. this study was designed to compare the effec...

normal 0 false false false en-us x-none ar-sa leishmaniasis is a protozoan infection due to organisms of the genus leishmania. the differential diagnosis of cutaneous leishmaniasis includes arthropod bites, basal cell carcinoma (bcc) and other malignancies. bcc is the most common form of skin cancer. we present a case of cutaneous leishmaniasis resistant to standard intralesional glucantime inj...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 colorectal cancer is classified in to three forms: sporadic (70-75%), familial (20-25%) and hereditary (5-10%). hereditary colorectal cancer syndromes classified into two different subtypes: polyposis and non polyposis. familial adenomatous polyposis (fap; omim #175100) is the most common polyposis syndrome, account for <1...

Due to the high prevalence and variable phenotype of patients with Klinefelter syndrome, there is a need for a robust and rapid screening method allowing early diagnosis. Here, we report on the development and detailed clinical validation of a quantitative real-time PCR (qPCR)-based method of the copy number assessment of the androgen receptor (AR) gene, located to Xq11.2-q12. We analysed sampl...

BACKGROUND Immunoglobulin E (IgE) is a central player in the allergic response, and raised total IgE levels are considered as an indicator of atopy or potential development of atopy. A recent genome-wide scan in a German population-based cohort of adults identified the gene encoding the alpha chain of the high affinity receptor for IgE (FCER1A) as a susceptibility locus influencing total serum ...

Background: To distinguish a basal cell carcinoma (BCC) from a trichoepithelioma (TE) can be diffi cult even for an experienced dermatopathologist. Objective: In this study, we sought to reconfi rm the androgen receptors (AR) immunostaining pattern of BCC and TE and to determine whether AR immunoreactivity could serve as a useful maker to differentiate these two tumors. Methods: Twenty-one case...

Mutations in the androgen receptor (AR) that enable activation by antiandrogens occur in hormone-refractory prostate cancer, suggesting that mutant ARs are selected by treatment. To validate this hypothesis, we compared AR variants in metastases obtained by rapid autopsy of patients treated with flutamide or bicalutamide, or by excision of lymph node metastases from hormone-naïve patients. AR m...

ing their permission to publish these cases. The histopathological examinations were performed at the National CJD Surveillance Unit by Dr James Ironside. Contributors: RdeS, JP, and DH raised the possibility of using single photon emission computed tomography as a diagnostic “pointer” in new variant Creutzfeldt-Jakob disease, and RdeS wrote the paper. AR, MT, and MZ discussed the core concept ...

The assembly process increases complex and Augmented Reality (AR) is applied in the to improve user’s experience by providing interactive instructions real time. However, none of previous studies developed AR application guide investigated complexity assembly. research develops an AR-guided provide instruction on a laptop. laptop was investigated. development involves creation model target, 3D ...