PURPOSE To evaluate the neuroprotective effect of intravitreal injections of neurotrophic factors secreting mesenchymal stem cells (NTF-SCs) on the survival of retinal ganglion cells (RGCs) in rat eyes after optic nerve transection (ONT). METHODS Rat and human bone marrow-derived mesenchymal stem cells (MSCs) were induced to secrete high levels of NTF. The neuroprotective effect from intravit...

The goal of the session on the visual system, as described by Dr. R. Lund in his introductory remarks, was to integrate the biology of the visual system with transplantation studies. The presentations were selected as examples of different approaches to transplantation which would bring together problems from both spheres. Dr. G. Bray, speaking in place of Dr. A. Aguayo on responses of injured ...

Optic nerve transection (ONT) triggers retinal ganglion cell (RGC) death. By using this paradigm, we have analyzed for the first time in adult albino and pigmented mice, the effects of ONT in the scotopic threshold response (STR) components (negative and positive) of the full-field electroretinogram. Two weeks after ONT, when in pigmented mice approximately 18% of the RGC population survive, th...

Acidic and basic fibroblast growth factors (aFGF and bFGF) are known to stimulate mitogenesis in a variety of non-neuronal cell types. Recent work has also established that FGFs can act as neurotrophic factors that promote the survival and regeneration in vitro of a variety of neurons. The present study investigates the distribution of aFGF and bFGF in vivo by using a mitogenic bioassay on AKR-...

A 14-year-old who had 7episodes of relapsing unita­leral paralysis of facial nerve during 7 year-;. was admit­ted to the hospital. The X-Ray revealed Osteopetrosis, and the bone biopsy was proved this diagnosis. But there was not any bone fracture, or anemia. Pressure over fa­cial nerve caused by condensation of entire facial nerve canal. was detected by tomographia. Probablv intermitant facial...

our previous studies have shown that median and ulnar nerve lesion induced calbindin (cb) immunoreactivity in some injured motoneurons in developing rats. motoneuron death induced by sciatic nerve transection in neonatal rats has been related to induction of neuronal isoform of nitric oxide synthase (nnos). the present study investigated whether expression of cb and nicotinomid adenin dinucleot...

objective: to determine the effects of local administration of platelet rich plasma (prp) on peripheral nerve regeneration in rat sciatic nerve transection model. methods: forty-five male white wistar rats were randomized into three experimental groups (n = 15): normal control group (nc), silicon group (sil), prp treated group (sil/prp). in nc group left sciatic nerve was exposed through a glut...

Objective- The objective was to assess local effect of brain derived neurotrophic factor (BDNF) on functional recovery of peripheral nerve in rat sciatic nerve transection model. Design- Experimental study. Animals- Sixty male healthy white Wistar rats Procedures- The animalswere randomized into four experimental groups of 15 animals each: In sham-operated group (SHAM), sciatic nerve was exp...

background sphenoid sinus is surrounded by many vital vascular and nervous structures. in more than 20% of patients with chronic sinusitis, involvement of sphenoid sinus has been observed. besides, sphenoid sinus is an appropriate route to access anterior and middle cranial fossa in surgery. therefore, it is important to have an adequate knowledge about the contents of sphenoid sinus and its pr...