Regeneration or extensive new growth of the pancreatic duct has been report,ed by Fisher (1924b), and regeneration of pancreas tissue (acini and islets) from the pancreatic duct tissue have been reported by several investigators, Languesse and de la Roche (1902), Cecil (1911), Bensley and Clark (1914). These observations deal with regeneration of pancreas from duct tissue left in situ, such as ...

Mechanism of most of herbal used for diabetes mellitus treatme was performed to investigate hypoglycemic effect of walnut leaf (Juglan sativum L.) or pomegranate seed (Punica granatum L.), and their poss mellitus was induced in 20 adult male Sprague Dawley rats and the anima them fed a diet supplemented with about15 gram (60 g/ kg body weight /d fourth diabetic untreated group (positive control...

For the past 30 years, data have suggested that unique islet populations exist, based on morphology and glucose sensitivity. Yet little has been done to determine the mechanism of these functional differences. The purpose of this study was to determine whether human islets were comprised functionally unique populations, and to elucidate a possible mechanism. Islets or pancreatic sections from 2...

OBJECTIVES One of the theories connecting enterovirus (EV) infection of human islets with type 1 diabetes (T1D) is the development of a fertile field in the islets. This implies induction of appropriate proteins for the viral replication such as the coxsackie-adenovirus receptor (CAR). The aim of this study was to investigate to what extent CAR is expressed in human islets of Langerhans, and wh...

As shown by transgenic mouse models and by using phosphodiesterase 3 (PDE3) inhibitors, PDE3B has an important role in the regulation of insulin secretion in pancreatic β-cells. However, very little is known about the regulation of the enzyme. Here, we show that PDE3B is activated in response to high glucose, insulin and cAMP elevation in rat pancreatic islets and INS-1 (832/13) cells. Activati...

Although cigarette smoking is associated with insulin resistance and an increased risk for type 2 diabetes, few studies have examined the effect of nicotine on the adult endocrine pancreas. In this study, male Wister rats were treated with nicotine (3 mg/kg body weight/ day) with or without supplementation of folic acid (36 μg/kg body weight/day) or vitamin B12 (0.63 μg/kg body weight/day) alon...

TABLE 1 Landmarks in the history of the islets of Langerhans 1869 First description of pancreatic islets by Langerhans 1902 First tumour of the islets described by Nicholls 1922 Discovery of insulin by Banting and Best 1923 Discovery of glucagon by Murlin and colleagues 1924 Harris postulates the possibility of insulinoma 1927 Wilder extracts insulin from a malignant pancreatic tumour explored ...