The three-dimensional (3D) structure of the genome is important for orchestration of gene expression and cell differentiation. While mapping genomes in 3D has for a long time been elusive, recent adaptations of high-throughput sequencing to chromosome conformation capture (3C) techniques, allows for genome-wide structural characterization for the first time. However, reconstruction of "consensu...

Background: Limb salvaging surgeries are current surgical treatment of extremity bone sarcomas. Resected bonereplacement consists of two main methods; tumor prosthesis versus structural allograft. Biological reconstruction withan allograft is an economic cheap method in young sarcoma patients, however, the surgeons are more convinced withtumor prosthesis replacement.Methods: We evaluated the sh...

Magnetic resonance imaging (MRI) is a versatile imaging technique that allows different contrasts depending on the acquisition parameters. Many clinical imaging studies acquire MRI data for more than one of these contrasts—such as for instance T1 and T2 weighted images—which makes the overall scanning procedure very time consuming. As all of these images show the same underlying anatomy one can...

in the poetics of aristotle, art and literature are imitations of reality and all literary elements have objective representation in the real world. following the theories of ferdinand de saussure and roman jakobson and formation of new literary approaches such as structuralism, there existed a modern poetics which didn’t consider literature as an imitation of reality but introduces it as recon...

there is controversy in the literature regarding a number of topics related to anterior cruciate ligament (acl)reconstruction. the purpose of this article is to answer the following questions: 1) bone patellar tendon bone (bptb) reconstruction or hamstring reconstruction (hr); 2) double bundle or single bundle; 3) allograft or authograft; 4) early or late reconstruction; 5) rate of return to sp...

Although near-atomic resolutions have been routinely achieved for structural determination of many icosahedral viral capsids, structures of genomes and associated proteins within the capsids are still less characterized because the genome information is overlapped by the highly symmetric capsid information in the virus particle images. We recently developed a software package for symmetry-misma...

We propose a new deformable shape model Active Shape Structural Model (ASSM) for recognition and reconstruction. The main features of ASSM are: (1) It describes variations of shape not only statistically as Active shape/Appearance model but also by structural variations. (2) Statistical and structural prior knowledge is integrated resulting in a multi-resolution shape description such that the ...

An uncemented hemispherical acetabular component is the mainstay of acetabular revision and gives excellent long-term results. Occasionally, the degree of acetabular bone loss means that a hemispherical component will be unstable when sited in the correct anatomical location or there is minimal bleeding host bone left for biological fixation. On these occasions an alternative method of reconstr...

PURPOSE To compare radiography with multidetector computed tomography (MDCT) in the evaluation of graft integration following acetabular reconstruction for failed total hip arthroplasty (THA). METHODS Records of 5 men and 6 women aged 60 to 78 (mean, 71.8) years who underwent acetabular reconstruction using structural allografts for severe acetabular deficiency secondary to aseptic loosening ...