BACKGROUND/AIMS There are no nationally agreed guidelines on preoperative management of patients who are on aspirin or warfarin therapy. There is considerable evidence that complication rates in anticoagulated patients are low whereas there are higher rates of thromboembolic complications in those whose therapy is manipulated. This survey aimed to establish oculoplastic specialist and non-speci...

Embolism of cardiac origin accounts for 20% of ischaemic strokes. Atrial fibrillation is by far the most common cause of cardioembolic stroke, and anticoagulation is the treatment generally indicated for secondary, and in many cases, primary prevention. 1 The decision to prescribe warfarin is usually based on an accurate assessment of the likely absolute annual risk of stroke without warfarin, ...

BACKGROUND Venous gangrene complicating deep vein thrombosis in the context of anticoagulation use in patients with gynecologic malignancy is rarely reported. We report an unusual presentation of venous gangrene of the lower limbs associated with warfarin therapy in a 53-year-old woman from the Cook Islands with an occult ovarian cancer. CASE PRESENTATION A 53-year-old woman of Cook Islands o...

Background: Warfarin has been widely used for a long time as an oral anticoagulant agent. Warfarin is reported to have inflammatory role as well. The dose of Warfarin plays an important role in up and down regulation of interacting cytokines such as IL-6 and COX-2 (Cyclooxygenase). Objective: To investigate the effects of varying Warfarin doses on IL-6 and COX-2. Material and Methods: Serum IL-...

PURPOSE To evaluate the effect of continuing warfarin therapy on the bleeding risk of patients undergoing elective dental surgical procedures. METHODS Data sources were the MEDLINE and EMBASE databases, the Cochrane Central Register of Controlled Trials, a manual citation review of the relevant literature, content experts and relevant abstracts from the proceedings of the International Associ...

Factor VII (FVII) deficiency is the most prevalent rare bleeding disorder in the USA and affects approximately 1 out of every 500,000 people. Warfarin inhibits the synthesis of FVII, in addition to other clotting factors. Warfarin is contraindicated in patients with bleeding tendencies or blood dyscrasias; therefore, the literature regarding the use of warfarin in FVII deficiency is very limite...

T he increasing recognition of the high risk of embolic stroke and other systemic emboli in patients with nonrheumatic atrial fibrilla-tion, the widespread experience with lower-intensity warfarin regimens, and the extensive evidence for the efficacy of aspirin in a variety of vascular diseases led to the conduction of seven large trials of warfarin, four of which also included an evaluation of...

Hemorrhagic complications due to warfarin use are frequently seen in emergency departments. However, nontraumatic massive hemothorax is an unexpected complication. We report a 59-year-old woman with warfarin overdose, who had massive hemothorax in right lung without any history of trauma. Her main complaint was significant dyspnea, which has gradually increased in three days. On her physical ex...

Atrial fibrillation, the commonest cardiac arrhythmia, predisposes to thrombus formation and consequently increases risk of ischaemic stroke. Recent years have seen approval of a number of novel oral anticoagulants. Nevertheless, warfarin and aspirin remain the mainstays of therapy. It is widely appreciated that both these agents increase the likelihood of bleeding: there is a popular conceptio...